73746-45-9

Basic information

• Product Name: 2-METHYL-4(5)-IODO-1(H)-IMIDAZOLE
• Synonyms: 2-METHYL-4(5)-IODO-1(H)-IMIDAZOLE;4-IODO-2-METHYL-1H-IMIDAZOLE;5-Iodo-2-methyl-1H-imidazole;4(5)-iodo-2-Methyl-1H-iMidazole;1H-IMidazole,4-iodo-2-Methyl-;4-Iodo-2-MethyliMidazole
• CAS NO: 73746-45-9
• Molecular Formula: C₄H₅IN₂
• Molecular Weight: 208
• Mol File: 73746-45-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 133 °C
• Boiling Point: 358.154 °C at 760 mmHg
• Flash Point: 170.406 °C
• Appearance: /
• Density: 2.094 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.656
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.30±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-4(5)-IODO-1(H)-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-4(5)-IODO-1(H)-IMIDAZOLE(73746-45-9)
• EPA Substance Registry System: 2-METHYL-4(5)-IODO-1(H)-IMIDAZOLE(73746-45-9)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• RIDADR: UN3263
• Hazardous Substances Data: 73746-45-9(Hazardous Substances Data)

Usage

General Description

2-Methyl-4(5)-iodo-1(H)-imidazole is a chemical compound with the molecular formula C4H5IN2. It is a derivative of imidazole and is commonly used as a building block in organic synthesis. It is a white to off-white crystalline powder with a molecular weight of 217.99 g/mol. The compound is primarily used in the pharmaceutical industry for the synthesis of various pharmaceuticals, including antifungal and antibacterial agents. It is also used as a reagent in the synthesis of other organic compounds and as a corrosion inhibitor. Additionally, 2-Methyl-4(5)-iodo-1(H)-imidazole has potential applications in the development of new materials and drug discovery.

InChI:InChI=1/C4H5IN2/c1-3-6-2-4(5)7-3/h2H,1H3,(H,6,7)

Upstream product

• 73746-44-8 4,5-diiodo-2-methyl-1H-imidazole 
• 693-98-1 2-methylimidazole 
• 109-72-8 n-butyllithium 

Downstream Products

• 111566-79-1 4-Iodo-2-methyl-1-(3-methyl-4-nitrophenyl)imidazole 
• 157255-72-6 4-iodo-2-methyl-1-triphenylmethylimidazole 
• 941287-07-6 1-benzyl-4-iodo-2-methyl-1H-imidazole 
• 808773-38-8 4-(3-chloro-phenylethynyl)-2-methyl-1H-imidazole 
• 102791-92-4 1-(3-methyl-4-nitro-phenyl)-1H-imidazole 
• 1167623-56-4 6-(2-methyl-1H-imidazol-4-yl)-N-phenylimidazo[1,2-a]pyridine-2-carboxamide 
• 1334675-68-1 4-iodo-2-methyl-1-phenyl-1H-imidazole 
• 1334675-69-2 1-phenyl-2-methyl-5-iodoimidazole 
• 13739-48-5 2-methyl-4-phenyl-1H-imidazole 
• 693-98-1 2-methylimidazole 

Relevant articles and documents

Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1

Indoleamine 2,3-dioxygenase 1 (IDO1), promoting immune escape of tumors, is a therapeutic target for the cancer immunotherapy. A number of IDO1 inhibitors have been identified, but only limited structural biology studies of IDO1 inhibitors are available t

Discovery of MK-5046, a potent, selective bombesin receptor subtype-3 agonist for the treatment of obesity

We report the development and characterization of compound 22 (MK-5046), a potent, selective small molecule agonist of BRS-3 (bombesin receptor subtype-3). In pharmacological testing using diet-induced obese mice, compound 22 caused mechanism-based, dose-

Substituted inmidazoles as bombesin receptor subtype-3 modulators

Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.