73756-58-8

Basic information

• Product Name: rac-1-Chlor-2-methyl-3-phenylpropan
• Synonyms: rac-1-Chlor-2-methyl-3-phenylpropan
• CAS NO: 73756-58-8
• Molecular Weight: 168.666
• Mol File: 73756-58-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: rac-1-Chlor-2-methyl-3-phenylpropan(CAS DataBase Reference)
• NIST Chemistry Reference: rac-1-Chlor-2-methyl-3-phenylpropan(73756-58-8)
• EPA Substance Registry System: rac-1-Chlor-2-methyl-3-phenylpropan(73756-58-8)

Safety Data

• Hazardous Substances Data: 73756-58-8(Hazardous Substances Data)

Upstream product

• 66051-14-7 (Z)-α-methyl-cinnamaldehyde 
• 22436-06-2 2-methyl-3-phenylpropanol 
• 1009-67-2 2-methyl-3-phenylpropanoic acid 
• 34917-00-5 2-benzyl-2-methylmalonic acid 

Downstream Products

• 85705-59-5 3-[4-(1,1-dimethylpentyl)-phenyl]-2-methylpropyl chloride 
• 855658-66-1 (2-methyl-3-phenyl-propyl)-malonic acid 
• 93273-41-7 4-methyl-5-phenylpentanoic acid 
• 24435-52-7 (2-methyl-3-phenyl-propyl)-malonic acid diethyl ester 

Relevant articles and documents

Syntheses and pharmacological activities of chiral fomocaines

The syntheses of two chiral fomocaines namely rac ({4-[2-methyl-3-(morpholin-4-yl)propyl]benzyl}-phenyl-ether (O/G 3) and rac {4-[1-methyl-3-(morpholin-4-yl)propyl]benzyl}-phenyl-ether) (O/G 5) are reported. These compounds are part of a new research program concerning the relation between chirality and local anaesthetic activity in the group of fomocaines. The yield over five steps is in the range of 9% (O/G 3) up to 19,2% (O/G 5). The racemates were resoluted via the diastereomeric salts formed with (+)- or (-)-camphersulfonic acid. The chromatographic resolution in analytical scale is successful using a Daicel OD-column. The enantiomers are stable. The surface anaesthesia of the racemates as well as of the enantiomeres is weaker in comparison with fomocaine. The rate of tissue irritation is higher. The LD50 (mouse i.v.) is in the range between 290-390 mg/kg, while fomocaine shows a LD50 value of 175 mg/kg.