73789-96-5

Basic information

• Product Name: ethyl α,α-difluoro-4-(trifluoromethyl)benzeneacetate
• Synonyms: ethyl α,α-difluoro-4-(trifluoromethyl)benzeneacetate
• CAS NO: 73789-96-5
• Molecular Weight: 268.183
• Mol File: 73789-96-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: ethyl α,α-difluoro-4-(trifluoromethyl)benzeneacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl α,α-difluoro-4-(trifluoromethyl)benzeneacetate(73789-96-5)
• EPA Substance Registry System: ethyl α,α-difluoro-4-(trifluoromethyl)benzeneacetate(73789-96-5)

Safety Data

• Hazardous Substances Data: 73789-96-5(Hazardous Substances Data)

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 667-27-6 Ethyl bromodifluoroacetate 
• 455-13-0 4-Iodobenzotrifluoride 
• 383-62-0 ethyl 2-chloro-2,2-difluoroacetate 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 145349-76-4 [4-(ethylsulfanyl)phenyl]boronic acid 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 73790-06-4 ethyl 2-oxo-2-(4-(trifluoromethyl)phenyl)acetate 

Downstream Products

• 2251-60-7 1-(bromodifluoromethyl)-4-(trifluoromethyl)benzene 
• 1004282-85-2 C₉H₈F₅N 
• 913574-42-2 N-(1-(2,2-difluoro-2-(4-(trifluoromethyl)phenyl)ethyl)piperidin-4-yl)-1H-pyrazolo-[3,4-d]pyrimidin-4-amine 
• 73790-11-1 α,α-difluoro-4-(trifluoromethyl)benzeneacetic acid 

Relevant articles and documents

A convenient synthetic approach to a novel class of aryldifluoromethyl pyrimidine derivatives containing strobilurin motif as insecticidal agents

A series of aryldifluoromethyl pyrimidine compounds containing strobilurin were synthesized through bioelectronic isometric design with azoxystrobin as the lead compound and a convenient approach to aryldifluoromethylpyrimidine intermediates was developed, which features mild reaction conditions and simple operation. The title compounds and aryldifluoromethylpyrimidine intermediates were characterized by NMR and HRMS. Both 7c and 7l of the preliminary screening tests showed 100% inhibition against Mythimna separata at 100 mg/L. At 20 mg/L, the lethal rate of 7l against Mythimna separata can be up to 80%.

Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling

Herein, a direct method for the synthesis of 3-fluoroindoles and 3,3-difluoroindolines from easily accessible 2,2-difluoro-2-phenyl ethan-1-amines is presented. This protocol was performed by Pd-catalyzed direct C-H/N-H coupling and employed picolinamide as a directing group. By controlling the temperature for this transformation, various 3,3-difluoroindolines and 3-fluoroindoles could be isolated with moderate to good yields.

Synthetic method of aromatic ring group or aromatic heterocyclic tetrazole

The synthetic method comprises the following steps: (1) reacting 1.0 eq of ArI or HArI with 1.2 eq of ethyl 2, 2-difluoroacetate in the presence of DMSO as a solvent and 4.0 eq of Cu under the protection of nitrogen at 30 DEG C and 50 DEG C, and purifying to obtain a first intermediate compound; (2) dissolving 1.0 eq of the first intermediate compound in a mixed solvent of THF and water, adding 2.0 eq of LiOH, reacting at room temperature for 2 hours, spin-drying the solvent, adding HCl until the pH value is equal to 3, and filtering to obtain a second intermediate compound; and (3) reacting 1.0 eq of the second intermediate compound with 2.0 eq of diphenyl azide phosphate in the presence of 2.5 eq of triethylamine by taking tert-butyl alcohol as a solvent to generate aromatic ring group or aromatic heterocyclic tetrazole. The invention provides a novel synthetic method of aromatic ring group or aromatic heterocyclic tetrazole, wherein a target compound can be more conveniently obtained, and reagents participating in the reaction are low in toxicity, mild in reaction condition, simple and safe in aftertreatment, good in product quality and suitable for large-scale production.