73789-98-7

Basic information

• Product Name: 2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester
• Synonyms: 2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester
• CAS NO: 73789-98-7
• Molecular Weight: 276.283
• Mol File: 73789-98-7.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester(73789-98-7)
• EPA Substance Registry System: 2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester(73789-98-7)

Safety Data

• Hazardous Substances Data: 73789-98-7(Hazardous Substances Data)

Usage

Ethyl ester derivative

Difluoroacetic acid The compound is derived from difluoroacetic acid by attaching an ethyl group to the molecule, which influences its chemical properties and reactivity.

Biphenyl group

[1,1'-biphenyl]-4-yl The presence of a biphenyl group in the structure contributes to the compound's unique properties and reactivity, making it a valuable building block in organic synthesis.

Building block in organic synthesis

Due to its unique structure and reactivity, the compound is often used as a starting material or intermediate in the synthesis of various organic compounds.

Applications in pharmaceutical industry

The compound can be utilized in the development of new drugs, as its structure and properties may be beneficial in creating novel therapeutic agents.

Production of specialty materials and chemicals

The compound may also be used in the production of specialized materials and chemicals for various industrial applications.

Hazardous if improperly managed

It is important to handle this compound with care, as it may pose risks to health and the environment if not properly managed or disposed of.

Upstream product

• 6244-53-7 ethyl (4-phenylphenyl)glyoxylate 
• 1591-31-7 4-iodo-biphenyl 
• 205865-67-4 α-(trimethylsilyl)difluoroacetic acid ethyl ester 
• 667-27-6 Ethyl bromodifluoroacetate 
• 3315-91-1 4-biphenylylmagnesium bromide 
• 5122-94-1 4-biphenylboronic acid 
• 201230-82-2 carbon monoxide 
• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 92-67-1 4-phenylalanine 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 17763-78-9 4-phenylphenyl triflate 
• 5202-78-8 acetylaminoethylene 
• 73286-71-2 N-(tert-butoxycarbonyl)-2,3-dihydropyrrole 
• 383-62-0 ethyl 2-chloro-2,2-difluoroacetate 

Downstream Products

• 2714-87-6 [1,1′-biphenyl]-4-carbonyl fluoride 
• 398-36-7 1-phenyl-4-(trifluoromethyl)benzene 
• 73790-13-3 α,α-difluoro-4-phenylbenzeneacetic acid 

Relevant articles and documents

Access to α,α-Difluoro-γ-amino Acids by Nickel-Catalyzed Reductive Aryldifluoroacetylation of N -Vinylacetamide

A nickel-catalyzed reductive aryldifluoroacetylation of N -vinylacetamide with ethyl chloro(difluoro)acetate and aryl iodides is described. This chelating amide carbonyl group-assisted strategy provides rapid access to a variety of protected α,α-difluoro-γ-amino acids that might have potential applications in peptide chemistry and protein engineering. An advantage of this method is its synthetic simplicity, with no preparation of organometallic reagents.

Nickel-catalyzed carbodifunctionalization of: N -vinylamides enables access to γ-amino acids

A nickel-catalyzed tandem reaction of N-vinylamides with arylboronic acids and bromodifluoroacetate has been developed. The use of amide carbonyl as a chelating group efficiently furnishes a series of protected α,α-difluoro-γ-amino acid esters. The reaction can also extend to bromoacetate and 2-bromomalonate. The advantages of this protocol are high functional group tolerance and a broad substrate scope, including a variety of N-vinylamides. In particular, the use of removable amide carbonyl groups provides potential opportunities for applications in peptide chemistry and protein engineering.

trans-Selective Aryldifluoroalkylation of Endocyclic Enecarbamates and Enamides by Nickel Catalysis

Efficient methods for the dicarbofuntionalization of the cyclic alkenes 2-pyrroline and 2-azetine are limited. Particularly, the dicarbofunctionalization of endocyclic enecarbamates to achieve fluorinated compounds remains an unsolved issue. Reported here is a nickel-catalyzed trans-selective dicarbofunctionalization of N-Boc-2-pyrroline and N-Boc-2-azetine, a class of endocyclic enecarbamates previously unexplored for transition metal catalyzed dicarbofunctionalization. The reaction can be extended to six- and seven-membered endocyclic enamides. A variety of arylzinc reagents and bromodifluoroacetate, and its derivatives, undergo the reaction, providing straightforward and efficient access to an array of pyrrolidine- and azetidine-containing fluorinated amino acids and oligopeptides, which may have applications in the life sciences.