73841-32-4

Basic information

• Product Name: 3-Iodopyridine-2-carboxylic acid
• Synonyms: 3-Iodopyridine-2-carboxylic acid;3-Iodopicolinic acid
• CAS NO: 73841-32-4
• Molecular Formula: C₆H₄INO₂
• Molecular Weight: 249.00593
• Product Categories: Pyridines
• Mol File: 73841-32-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 350 °C at 760 mmHg
• Flash Point: 165.5 °C
• Appearance: /
• Density: 2.123 g/cm³
• Vapor Pressure: 1.69E-05mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-Iodopyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Iodopyridine-2-carboxylic acid(73841-32-4)
• EPA Substance Registry System: 3-Iodopyridine-2-carboxylic acid(73841-32-4)

Safety Data

• Hazardous Substances Data: 73841-32-4(Hazardous Substances Data)

Usage

General Description

3-Iodopyridine-2-carboxylic acid is a chemical compound with the formula C6H4INO2. It is a derivative of pyridine, containing an iodine atom and a carboxylic acid group attached to the second carbon atom of the pyridine ring. 3-Iodopyridine-2-carboxylic acid is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also a valuable building block for the preparation of heterocyclic compounds and is used in organic synthesis. 3-Iodopyridine-2-carboxylic acid is a white to off-white solid with a melting point of approximately 215 degrees Celsius. It is typically stored and handled under inert atmosphere due to its sensitivity to moisture and air.

InChI:InChI=1/C6H4INO2/c7-4-2-1-3-8-5(4)6(9)10/h1-3H,(H,9,10)

Upstream product

• 1462-86-8 3-amino-pyridine-2-carboxylic acid 
• 57841-90-4 3-iodo-N-phenyl-2-pyridinecarboxamide 
• 98-98-6 2-Picolinic acid 
• 10354-53-7 N-phenylpicolinamide 

Downstream Products

• 73841-41-5 3-iodo-pyridine-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide

Several unnatural derivatives of narciclasine were prepared in which the C-7 carbon was replaced with nitrogen. The 7-aza derivative and its N-oxide were prepared by the coupling of iodopicolinic acid with a conduramine unit derived chemoenzymatically from bromobenzene. Intramolecular Heck reaction was used to construct the isocarbostyryl ring system. The compounds were submitted to biological screening against cancer cell lines. Full experimental and spectra data are provided for all new compounds.

Piperazine Heteroaryl Derivatives as Gpr38 Agonists

The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Z, X and B are as defined in the specification. The compounds are partial or full agonists at the GPR38 receptor. Pharmaceutical compositions comprising the compounds, methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.

ADAMANTYL DERIVATES AS P2X7 RECEPTOR ANTAGONISTS

The invention provides compounds of formula (I) pharmaceutically acceptable salt or solvate thereof, in which R1, A1, m and A are as defined in the specification; a process for their preparation; pharmaceutical compositions containin