73857-20-2 Usage
Description
RANITIDINE-N-OXIDE, also known as Ranitidine EP Impurity E, is a metabolite of Ranitidine (R120000). It is characterized by its orange solid appearance. RANITIDINE-N-OXIDE is a compound that is derived from the metabolism of Ranitidine, a well-known medication used in the treatment of various conditions related to the gastrointestinal system.
Uses
Used in Pharmaceutical Industry:
RANITIDINE-N-OXIDE is used as an impurity reference substance for the quality control and assessment of Ranitidine products. Its presence in the pharmaceutical formulation is essential to ensure the purity, safety, and efficacy of the drug. As a metabolite, it also provides valuable information for understanding the pharmacokinetics and pharmacodynamics of Ranitidine in the body.
Used in Research and Development:
RANITIDINE-N-OXIDE serves as a crucial compound in the research and development of new drugs and therapies related to gastrointestinal disorders. Its chemical properties and metabolic profile can be studied to design more effective and safer medications for patients suffering from conditions such as peptic ulcers, gastroesophageal reflux disease (GERD), and other acid-related disorders.
Used in Quality Control Laboratories:
RANITIDINE-N-OXIDE is used as a reference standard in quality control laboratories to verify the identity, purity, and potency of Ranitidine in various pharmaceutical products. This helps to maintain the highest standards of drug quality and compliance with regulatory requirements, ensuring that patients receive safe and effective treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 73857-20-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,8,5 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 73857-20:
(7*7)+(6*3)+(5*8)+(4*5)+(3*7)+(2*2)+(1*0)=152
152 % 10 = 2
So 73857-20-2 is a valid CAS Registry Number.
73857-20-2Relevant articles and documents
Kinetics of ranitidine metabolism in dog and rat isolated hepatocytes
Cross,Bell,Wilson
, p. 367 - 375 (1995)
Freshly isolated hepatocytes from rat and dog have been evaluated as a model for the metabolism of ranitidine in vivo. Isolated hepatocytes from the male and female dog and male Wistar and random hooded rat metabolized ranitidine to ranitidine N-oxide, ranitidine S-oxide, desmethyl-ranitidine and two unidentified minor metabolites. The furoic acid metabolite of ranitidine, previously reported to be a minor metabolite in vivo in rat and dog, was not detected in hepatocytes from either species. The kinetics for ranitidine metabolism in hepatocytes were monophasic for the formation of the three major metabolites in dog and Wistar rat and for N-demethylation of ranitidine in the random hooded rat, but biphasic in this latter strain for the N- and S-oxidation of ranitidine. Ranitidine N-oxide was reduced to ranitidine by Wistar rat hepatocytes but not by hepatocytes from the random hooded rat or dog. Ranitidine S-oxide was metabolized by hepatocytes from both species to one of the unidentified metabolites but was not reduced to ranitidine in either species. Desmethylranitidine was not a substrate for metabolism in hepatocytes from either species. The relative quantitative importance of ranitidine N-oxide, ranitidine S-oxide and desmethylranitidine produced by the hepatocytes was consistent with the profiles of these three metabolites in vivo in rat and dog. The results confirm the value of isolated hepatocytes as a predictive model for in vivo drug metabolism.
