73899-15-7Relevant articles and documents
Synthesis of an [125I]-labelled derivative of MK-571, a tool for LTD4 receptor studies
Li,Leblanc,Zamboni,Young
, p. 537 - 544 (1994)
An [125I]-labelled derivative of MK-571 2 was synthesized from the arylstanne derivative 11 in 50% radiochemical yield. Compound 2 is a useful tool for LTD4 receptor studies. The arylstanne intermediate 11 was obtained from the coupl
Synthesis of some nitroimidazole substituted boronic acids: Precursors to technetium-99m complexes with potential for imaging hypoxic tissue
Raju,Ramalingam,Nowotnik
, p. 10233 - 10238 (1992)
A number of nitroimidazole substituted alkyl and aryl-boronic acids were synthesized as precursors to technetium-99m complexes under investigation as potential imaging agents of hypoxia. Compounds were prepared with nitro group either in the 2- or 4-posit
Nitroxide derivative of ROCK kinase inhibitor
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Paragraph 0357-0363, (2020/06/17)
The invention provides a small molecular compound of a NO donor. The small molecular compound is characterized in that the small molecular compound is a compound shown represented by structural formula I shown in the description, or a stereoisomer, a geometrical isomer, a tautomer, a racemate, a deuterated isotope derivative, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof; and in the formula I, ring A is a substituted or unsubstituted heteroaromatic ring, X is selected from (CH2)n, n is selected from 0, 1, 2 and 3, R is a substituent group of terminal -O-NO2, R is selected from hydrogen, a hydroxyl group, halogen, an amino group, a cyano group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group and a substituted or unsubstituted heteroalkyl group, and R and R are respectively and independently selected from hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted naphthenic base or an amino protecting group, or R and R are connected to form a substituted or unsubstituted cyclic heteroalkyl group. The compound has a high-activity inhibition effect on ROCK kinase.
ANTIMICROBIAL COMPOUNDS AND METHODS
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Paragraph 00360, (2020/07/31)
The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.