73901-67-4 Usage
Description
1-(chloromethyl)pyrazole hydrochloride is a pyrazole derivative chemical compound that contains a chloromethyl group and a hydrochloride salt. It is utilized in scientific research and holds potential applications in the pharmaceutical industry due to its unique properties and interactions.
Uses
Used in Pharmaceutical Industry:
1-(chloromethyl)pyrazole hydrochloride is used as a selective antagonist for the cannabinoid CB2 receptor, which makes it a potential candidate for the development of new medications. This application is due to its ability to modulate the CB2 receptor, which is involved in various physiological processes.
Used in Pain Management:
1-(chloromethyl)pyrazole hydrochloride is used as a therapeutic agent for pain management, particularly in conditions where the CB2 receptor plays a significant role in pain transmission and modulation.
Used in Inflammation Treatment:
As an antagonist of the CB2 receptor, 1-(chloromethyl)pyrazole hydrochloride is used in the treatment of inflammatory conditions, where the CB2 receptor is implicated in the regulation of inflammation.
Used in Neurodegenerative Disease Treatment:
1-(chloromethyl)pyrazole hydrochloride is used as a potential therapeutic agent for neurodegenerative diseases, given the involvement of the CB2 receptor in neuroprotection and the compound's potential to modulate this receptor.
Used in Cancer Treatment:
1-(chloromethyl)pyrazole hydrochloride is used as an inducer of apoptosis in cancer cells, suggesting its potential as a cancer treatment. This application is based on the compound's ability to trigger programmed cell death in cancerous cells, thereby inhibiting tumor growth and progression.
Further research is necessary to fully comprehend the potential uses and limitations of 1-(chloromethyl)pyrazole hydrochloride in these applications.
Check Digit Verification of cas no
The CAS Registry Mumber 73901-67-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,9,0 and 1 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 73901-67:
(7*7)+(6*3)+(5*9)+(4*0)+(3*1)+(2*6)+(1*7)=134
134 % 10 = 4
So 73901-67-4 is a valid CAS Registry Number.
73901-67-4Relevant articles and documents
Pyrazolyl-N-heterocyclic carbene complexes of rhodium as hydrogenation catalysts: The influence of ligand steric bulk on catalyst activity
Page, Michael J.,Wagler, Joerg,Messerle, Barbara A.
experimental part, p. 7029 - 7038 (2010/01/06)
A series of bidentate 1-(1-pyrazolylmethyl)-substituted NHC ligands (13a-c, 14a-c and 15a-c) were synthesised with substituents of varying steric bulk incorporated adjacent to the donor atoms. These ligands were coordinated to rhodium(I) to give a series of complexes of the general formula [Rh(L)(COD)]BPh4 (where L = a mixed-donor pyrazolyl-NHC ligand and COD = 1,5-cyclooctadiene). The solid state structures of [Rh(13b)(COD)]BPh 4 (16b), [Rh(13c)(COD)]BPh4 (16c), [Rh(14a)(COD)]BPh 4 (17a), [Rh(14b)(COD)]BPh4 (17b), [Rh(15a) 2(COD)]BPh4 (18a), and [Rh(15b)(COD)]BPh4 (18b) were determined by single crystal X-ray diffraction. The complex [Rh(15a) 2(COD)]BPh4 (18a) is unusual in that two of the pyrazolyl-NHC ligands (15a) are coordinated to the metal through the NHC donor instead of one ligand forming the expected chelate. These complexes (with the exception of 18a) were found to be effective catalysts for the hydrogenation of styrene. The catalytic activity was correlated with complex structure, and it was found that the greater the steric bulk of the metal bound ligand, the slower the rate of the hydrogenation.
A SELECTIVE SYNTHESIS OF UNSYMMETRICAL 1,1'-METHYLENEBISDIAZOLES BY SOLID-LIQUID PHASE TRANSFER CATALYSIS
Julia, Sebastian,Martinez-Martorell, Carlos,Elguero, Jose
, p. 2233 - 2237 (2007/10/02)
1,1'-Methylenebisdiazoles Az1-CH2-Az2, Az1 and Az2 being two different diazoles, can be prepared selectively in three steps, through 1-hydroxymethyl- and 1-chloromethyldiazoles, by solid-liquid (S-L) phase transfer catalysis.