73903-30-7

Basic information

• Product Name: 8-Methoxy-2-methyl-1,2,3,4-tetrahydroisochinolin
• CAS NO: 73903-30-7
• Molecular Weight: 177.246
• Mol File: 73903-30-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 8-Methoxy-2-methyl-1,2,3,4-tetrahydroisochinolin(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Methoxy-2-methyl-1,2,3,4-tetrahydroisochinolin(73903-30-7)
• EPA Substance Registry System: 8-Methoxy-2-methyl-1,2,3,4-tetrahydroisochinolin(73903-30-7)

Safety Data

• Hazardous Substances Data: 73903-30-7(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 121587-38-0 2-(2-trimethylsilyl-3-methoxyphenyl)ethylamine 
• 73903-29-4 Diathyl-(8-methoxy-2-methyl-1,2,3,4-tetrahydroisochinolin-6-yl)-phosphat 
• 73903-24-9 6,8-dimethoxy-3,4-dihydroisoquinoline 
• 73903-28-3 6-Hydroxy-8-methoxy-2-methyl-1,2,3,4-tetrahydroisochinolin 
• 3213-28-3 3,5-dimethoxyphenethylamine 
• 73903-26-1 6,8-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisochinolin-hydrochlorid 
• 73903-22-7 N-<2-(3,5-Dimethoxyphenyl)athyl>-trifluoracetamid 
• 73903-23-8 N-<2-(2-Formyl-3,5-dimethoxyphenyl)athyl>-trifluoracetamid 
• 122888-68-0 [2-Methoxy-6-((E)-2-nitro-vinyl)-phenyl]-trimethyl-silane 
• 113337-61-4 3-Methoxy-2-trimethylsilanyl-benzaldehyde 
• 74904-29-3 8-methoxy-3,4-dihydroisoquinolin-1(2H)-one 
• 33543-63-4 ethyl-N-<2-(3-methoxyphenyl)ethyl>-carbamate 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 

Relevant articles and documents

Tyrosine Kinase Inhibitor And Uses Thereof

Disclosed is a compound of Formula (I) or a pharmaceutically acceptable salt, ester, or solvate thereof, or their stereoisomers, which can be used as tyrosine kinase inhibitor. Also disclosed is a method for preparing the compound, a pharmaceutical composition and a kit comprising the compound, and uses of the compound. The compound can be used as tyrosine kinase inhibitor, or can be used to reduce or inhibit activity of EGFR or mutant thereof, such as EGFR mutant comprising T790M mutation, in a cell, or to treat and/or prevent a disease associated with overactivity of EGFR, such as cancer.

30. Eine neue Synthese von 8-Hydroxy-2-methyl-1,2,3,4-tetrahydroisochinolin

Vilsmeier formylation of N--trifluoroacetamide (5) yielded the aldehyde 6, which under mild basic conditions was hydrolyzed to 7 and cyclized to 6,8-dimethoxy-3,4-dihydroisoquinoline (3).Methylation of 3 and reduction of the