73945-73-0

Basic information

• Product Name: O-Isopropyliden-D-glycerinsaeurechlorid
• CAS NO: 73945-73-0
• Molecular Weight: 164.589
• Mol File: 73945-73-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: O-Isopropyliden-D-glycerinsaeurechlorid(CAS DataBase Reference)
• NIST Chemistry Reference: O-Isopropyliden-D-glycerinsaeurechlorid(73945-73-0)
• EPA Substance Registry System: O-Isopropyliden-D-glycerinsaeurechlorid(73945-73-0)

Safety Data

• Hazardous Substances Data: 73945-73-0(Hazardous Substances Data)

Upstream product

• 14028-61-6 Kaliumsalz der O-Isopropyliden-D-glycerinsaeure 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 
• 114746-70-2 (R)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 
• 14028-61-6 potassium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 

Downstream Products

• 104017-05-2 phenyl 1,2-O-isopropylidene-D-glycerate 
• 949087-01-8 (+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}bis{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]carboxamide} 
• 73945-72-9 Benzoic acid 2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-ethyl ester 
• 97652-54-5 N-(O-Isopropyliden-D-glyceroyl)-(S-benzyl)-L-cystein 
• 97652-53-4 N-(O-Isopropyliden-D-glyceroyl)-L-phenylalanin 
• 201420-74-8 [(R)-2,2-dimethyl-1,3-dioxolan-4-yl](phenyl)methanol 
• 170164-82-6 (R)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-phenylpropan-1-one 
• 16354-97-5 [(R)-2,2-dimethyl-1,3-dioxolan-4-yl]phenylmethanone 
• 97652-49-8 N-(O-Isopropyliden-D-glyceroyl)-L-phenylalanin-tert-butylester 
• 97652-46-5 N-(O-Isopropyliden-D-glyceroyl)-(S-benzyl)-L-cysteinmethylester 
• 97652-45-4 N-(O-Isopropyliden-D-glyceroyl)-L-phenylalaninmethylester 
• 148065-34-3 (R)-2,2-dimethyl-1,3-dioxolane-4-carboxamide 
• 533-50-6 D-erythrulose 

Relevant articles and documents

Preparation method of sofosbuvir key intermediate

The invention discloses a preparation method of a sofosbuvir key intermediate ((2R,3R,4R,5R)-3-(benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl)benzoic acid methyl ester. The preparation method comprises the following steps: by using (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid as a starting material, performing acylating chlorination, performing a reaction with alpha-fluoropropionic acid, performing carbonyl reduction, performing hydroxyl protection, performing hydrolytic cyclization, performing hydroxymethyl protection, performing reduction, and performing chlorination to prepare the sofosbuvir key intermediate ((2R,3R,4R,5R)-3-(benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl)benzoic acid methyl ester. The preparation scheme has a short synthetic route and a high yield, and avoids a fluorination reaction step in the synthetic process.

A route to homochiral (S)-O-methyl mandelic acid and related α-alkoxy carboxylic acids from isopropylidene glycerol

An improved synthesis of the useful ketones 7 is described. These ketones are then further modified via a highly stereospecific reduction to give homochiral α-alkoxy carboxylic acids which are useful chiral auxiliaries and intermediates.

N-Acylation of Amino Acids with Glyceric Acid

Several amino acid esters were N-acylated by isopropylidene-D-glyceric acid chloride.The various blocking groups were selectively removed to yield N-D-glyceroyl-amino acids which are able to intra- or intermolecular condensation. - Keywords: N-(O-Isopropy