7397-22-0Relevant articles and documents
Dependence of thermotropic mesomorphism on varying rigidity of central bridge in liquid crystals
Pandya,Patel
, p. 86 - 94 (2016)
A novel liquid crystalline(LC) homologous series of chalconyl esters: RO-C6H4-COO-C6H4-CH = CH-CO-C6H4F has been synthesized and studied with a view to understanding and establishing the relationship between thermotropic LC properties and molecular structure with reference to varying molecular rigidity due to linking groups. The novel homologous series consists of eleven members (C1 to C16). C1 and C2 homologues are nonliquid crystals (NLC) and the rest of the homologues are enantiotropically nematic (C3 to C16). The smectogenic character, either in enantiotropic or monotropic manner is totally absent for a series. Transition temperatures and textures of nematic phase were determined by an optical polarizing microscope (POM) equipped with a heating stage. Textures of the nematic phase are threaded or Schlieren. The analytical, thermal and spectral data support the molecular structures. Cr-N/I and N-I transition curves behaved in normal manner except for the C14 homologue. N-I transition curve exhibits an odd- even effect with a negligible deviating effect from the C10 homologue. Thermal stability for the nematic is 105.2°C and mesophase lengths range from 06.0°C to 46.0°C at C8 and C14 homologues respectively. The group efficiency order derived for nematic from the comparative study of present novel series with structurally similar analogous series on the basis of thermal stability as under.
Antibacterial and anti-inflammatory activity of valproic acid-pyrazole conjugates as a potential agent against periodontitis
Dai, Xinxiang,Dong, Lei,Fang, Ling,Wang, Jia,Xu, Pei,Zhang, Jia
, (2021/07/10)
Periodontitis is a serious global concern. Therefore, in the present study, we intend to synthesize novel valproic-acid pyrazole conjugates as a novel agent against periodontitis. The molecules were developed in a facile synthetic route and obtained in ex
Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation
Moi, Davide,Nocentini, Alessio,Deplano, Alessandro,Balboni, Gianfranco,Supuran, Claudiu T.,Onnis, Valentina
, (2019/08/30)
Four new series of aromatic sulfamates were synthesized and investigated for the inhibition of four human (h) isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), hCA I, II, IX, and XII. The reported derivatives, obtained by a sulfamoylation reaction of the corresponding phenolic precursors, bear 3,5-diarylpyrazoline moieties as spacers between the benzenesulfamate fragment which binds the zinc ion from the active site, and the tail of the inhibitor. Pyrazolines are biologically privileged scaffolds, endowed with versatile biological activity, such as an anti-proliferative action. The derivatives were tested for the inhibition of the cytosolic, hCA I and II (off target isoforms) and the trans-membrane, tumor-associated hCA IX and XII enzymes (anticancer drug targets). Generally, hCA I was not effectively inhibited, whereas many low nanomolar inhibitors were evidenced against hCA II (KIs in the range of 0.42–90.1 nM), IX (KIs in the range of 0.72–63.6 nM), and XII (KIs in the range of 0.88–85.2 nM). The best substitution fragments at the pyrazoline ring included for CA II a 4-sulfamic group on the 3-aryl and halogens on the 5-aryl or a methoxy group on the 3-aryl and a 4-sulfamate group on the 5-aryl; for CA IX and CA XII they included the sulfamic group on the 3- or 4-position of the 5-aryl and an electronwithdrawing group on the 4-postion of the 3-aryl ring.
