73998-02-4Relevant articles and documents
Cleavage of esters using carbonates and bicarbonates of alkali metals: Synthesis of thymopentin
Kaestle,Anwer,Audhya,Goldstein
, p. 327 - 330 (1991)
A novel method for hydrolysis of primary esters using aqueous alkali carbonates or bicarbonates and an alcohol as cosolvent is described. Several peptide esters, including a Cbz-Arg-Lys(Cbz)-Asp(OBzl)-Val-Tyr-OBzl (sequence corresponding to the active site of thymic immunoregulatory hormone, thymopoietin), were hydrolyzed to demonstrate the utility of this method.