74003-63-7

Basic information

• Product Name: 3-Methyl-quinoxaline-2-carboxylic Acid
• Synonyms: 3-Methyl-2-quinoxalinecarboxylic Acid;MQCA;RCG-210;RCG-210, MQCA;MQCA Solution, 1000ppm
• CAS NO: 74003-63-7
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.19
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 74003-63-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 168-170°C
• Boiling Point: 347.1°C at 760 mmHg
• Flash Point: 163.7°C
• Appearance: /
• Density: 1.355g/cm³
• Vapor Pressure: 2.08E-05mmHg at 25°C
• Refractive Index: 1.673
• Storage Temp.: -20°C Freezer
• PKA: 2.37±0.30(Predicted)
• CAS DataBase Reference: 3-Methyl-quinoxaline-2-carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-quinoxaline-2-carboxylic Acid(74003-63-7)
• EPA Substance Registry System: 3-Methyl-quinoxaline-2-carboxylic Acid(74003-63-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 74003-63-7(Hazardous Substances Data)

Usage

Description

3-Methylquinoxaline-2-carboxylic acid (MQCA) is a major metabolite of olaquindox, an antibiotic and swine growth regulator. It is a yellow solid that induces cell cycle arrest at the S phase and exhibits toxicity to Chang liver cells in a concentrationand time-dependent manner. MQCA serves as a marker for the detection of olaquindox use in livestock applications.

Uses

Used in Agricultural Industry:
3-Methylquinoxaline-2-carboxylic acid is used as a marker compound for the detection of olaquindox use in livestock applications. This helps in monitoring and ensuring the safety and quality of meat products derived from treated animals.
Used in Research and Development:
MQCA is utilized in research studies to understand the effects of olaquindox metabolites on cell cycle regulation and toxicity. This aids in the development of safer and more effective alternatives to olaquindox in animal husbandry and agriculture.

InChI:InChI=1/C10H8N2O2/c1-6-9(10(13)14)12-8-5-3-2-4-7(8)11-6/h2-5H,1H3,(H,13,14)

Upstream product

• 2379-55-7 2,3-dimethylquinoxaline 
• 480-96-6 benzofurazan oxide 
• 24309-97-5 N-(2-hydroxyethyl)-3-oxobutanamide 
• 25519-55-5 3-methylquinoxaline-2-carbaldehyde 
• 7446-08-4 selenium(IV) oxide 
• 108-38-3 m-xylene 
• 3885-38-9 2-methyl-3-ethoxycarbonylquinoxaline 
• 13297-18-2 2-ethoxycarbonyl-3-methylquinoxaline 1,4-dioxide 
• 88-74-4 2-nitro-aniline 
• 61522-54-1 methyl 3-methylquinoxaline-2-carboxylate 

Relevant articles and documents

Preparation method of high-purity 3-methylquinoxaline-2-carboxylic acid

The invention discloses a preparation method of high-purity 3-methylquinoxaline-2-carboxylic acid. The preparation method comprises the following steps: enabling a compound shown as a formula III to react with acetate to obtain a compound shown as a formula II; enabling the compound shown as the formula II to react with o-phenylenediamine under an acidic condition to prepare a compound shows as aformula I; then, preparing the 3-methylquinoxaline-2-carboxylic acid from the compound shown as the formula I. The preparation method has the advantages of short process route, easiness and convenience in operation, mild conditions, readily-available raw materials, and higher yield and purity of the obtained product. As proved by results of qualitative and quantitative analysis performed on the product by the analysis measures of magnetic resonance imaging, high performance liquid chromatography, gas chromatography and the like, the moisture and solvent residue content in the product are extremely low, and a sample has high uniformity and storage stability, and meets the requirement as a standard product. The formulas I, II and III are shown in the description.

Fluorinated lysine derivatives as dipeptidyl peptidase IV inhibitors

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An Improved and Efficient Synthesis of Quinoxalinecarboxamide 1,4-Dioxides from Benzofuroxan and Acetoacetamides in the Presence of Calcium Salts

An improved and efficient method for the preparation of the title compounds 3 is described.Thus, quinoxalinecarboxamide 1,4-dioxides 3 are synthesized in high yields by reaction of benzofuroxan 1 with acetoacetamides 2 in the presence of catalytic amounts of calcium salts and ethanolamine.The reaction is assumed to involve a chelate mechanism with 4 as intermediate.Side reactions are studied by means of HPLC and TLC.