74031-42-8

Basic information

• Product Name: Benzene, (3,3,3-trifluoro-1-propenyl)-, (Z)-
• CAS NO: 74031-42-8
• Molecular Formula: C9H7F3
• Molecular Weight: 172.15
• Mol File: 74031-42-8.mol
• Article Data: 55

Chemical Properties

• CAS DataBase Reference: Benzene, (3,3,3-trifluoro-1-propenyl)-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (3,3,3-trifluoro-1-propenyl)-, (Z)-(74031-42-8)
• EPA Substance Registry System: Benzene, (3,3,3-trifluoro-1-propenyl)-, (Z)-(74031-42-8)

Safety Data

• Hazardous Substances Data: 74031-42-8(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 677-21-4 1,1,1-trifluoropropylene 
• 2314-97-8 iodotrifluoromethane 
• 66680-87-3 (E)-1-phenyl-(2-tributylstannyl)ethene 
• 100-52-7 benzaldehyde 
• 135654-55-6 2,2,2-trifluoroethyltriphenylphosphonium trifluoromethanesulfonate 
• 887144-94-7 Togni's reagent II 
• 536-74-3 phenylacetylene 
• 15458-53-4 trifluoromethanesulfonyl bromide 
• 103-64-0 bromostyrene 
• 75-63-8 Bromotrifluoromethane 
• 622-25-3 1-(2-chlorovinyl)benzene 
• 88986-32-7 methyl 3-oxa-ω-fluorosulfonylperfluoropentanoate 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 

Downstream Products

• 718-35-4 1-nitro-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene 
• 2338-79-6 1-phenyl-1,2-dichloro-3,3,3-trifluoropropane 
• 3238-20-8 (1-bromo-3,3,3-trifluoropropyl)benzene 
• 34091-69-5 [(1E)-2-chloro-3,3,3-trifluoro-1-propenyl]benzene 
• 34093-70-4 (Z)-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)benzene 
• 103826-30-8 1-phenyl-1,2,2-trichloro-3,3,3-trifluoropropane 
• 103826-32-0 (Z)-1-phenyl-1,2-dichloro-3,3,3-trifluoropropene 
• 103826-31-9 (E)-1-phenyl-1,2-dichloro-3,3,3-trifluoropropene 
• 772-62-3 3,3,3-trifluoro-1-phenylpropyne 
• 718-65-0 3,3,3-Trifluor-1,1,2,2-tetrachlor-1-phenyl-propan 
• 3617-07-0 1-(1-bromo-3,3,3-trifluoropropyl)-4-nitrobenzene 
• 2003-07-8 [2-bromo-3,3,3-trifluoro-1-propenyl]benzene 
• 712-47-0 1.2-Dibrom-2-trifluormethyl-1-phenyl-ethylen 
• 1338939-09-5 N,N-dibenzyl-1,1,1-trifluoro-3-phenylpropan-2-amine 

Relevant articles and documents

A Readily Available Trifluoromethylation Reagent and Its Difunctionalization of Alkenes

Trifluoromethyl substitution is notably popular in pharmaceuticals and agrochemicals; however, trifluoromethylated compounds normally rely on the use of cost-prohibitive or gaseous trifluoromethylating reagents, which diminishes the general applicability of these methods. Herein an efficient trifluoromethylation reagent trifluoromethylsulfonyl-pyridinium salt (TFSP) was reported, which can be readily prepared from cheap and easily available bulk industrial feedstocks. TFSP can generate a trifluoromethyl radical under photocatalysis and realize the effective azido- or cyano-trifluoromethylation reactions of alkenes.

Deoxyfluorination of acyl fluorides to trifluoromethyl compounds by FLUOLEAD/Olah's reagent under solvent-free conditions

A new protocol enabling the formation of trifluoromethyl compounds from acyl fluorides has been developed. The combination of FLUOLEAD and Olah's reagent in solvent-free conditions at 70 °C initiated the significant deoxyfluorination of the acyl fluorides and resulted in the corresponding trifluoromethyl products with high yields (up to 99%). This strategy showed a great tolerance for various acyl fluorides containing aryloyl, (heteroaryl)oyl, or aliphatic acyl moieties, providing good to excellent yields of the trifluoromethyl products. Synthetic drug-like molecules were also transformed into the corresponding trifluoromethyl compounds under the same reaction conditions. A reaction mechanism is proposed.

Electrochemical Synthesis Strategy for Cvinyl-CF3 Compounds through Decarboxylative Trifluoromethylation

An efficient decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids using the Langlois reagent as a trifluoromethyl precursor has been achieved by an electro-oxidative strategy. Under catalyst-free and external oxidant-free electrolysis