740842-50-6

Basic information

• Product Name: 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one
• Synonyms: 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one;2-Nitro-5,6,8,9-tetrahydro-benzocyclohepten-7-one;3-nitro-5,6,8,9-tetrahydrobenzo[7]annulen-7-one;2-Nitro-5,6,8,9-tetrahydro-benzocyclohepten-7-o
• CAS NO: 740842-50-6
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.20994
• Mol File: 740842-50-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one(740842-50-6)
• EPA Substance Registry System: 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one(740842-50-6)

Safety Data

• Hazardous Substances Data: 740842-50-6(Hazardous Substances Data)

Usage

Description

2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one, also known as 2-nitrodibenz[b,f]oxepin-10(6H)-one, is a nitroaromatic compound with the molecular formula C14H9NO4. It features a benzene ring fused to a seven-membered ring containing an oxygen atom. This yellow crystalline solid is insoluble in water but soluble in organic solvents, and it is known for its unique chemical properties, electronic and optical characteristics.

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows it to be a valuable component in the development of new drugs and pesticides.
Used in Organic Electronic Devices and Materials:
Due to its electronic and optical properties, 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one has potential applications in the field of organic electronics. It can be incorporated into devices and materials that leverage its properties for improved performance or novel functionalities.
Caution:
Given its potential toxicological effects, 2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one should be handled with care in laboratory settings to ensure the safety of researchers and the environment.

Upstream product

• 37949-03-4 5,6,8,9-tetrahydrobenzo[7]annulen-7-one 
• 91-13-4 α,α'-dibromo-o-xylene 
• 24790-66-7 dimethyl 1,2,4,5-tetrahydro-3-oxobenzocycloheptene-2,4-dicarboxylate 

Downstream Products

• 740842-51-7 2-amino-5,6,8,9-tetrahydrobenzo[7]annulen-7-one 
• 1037624-75-1 R428 
• 1037627-96-5 phenyl (S)-N'-cyano-N-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)carbamimidate 
• 1037627-95-4 phenyl N'-cyano-N-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)carbamimidate 

Relevant articles and documents

AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER

This invention is directed to methods of preventing, treating or managing cancer, preferably metastatic cancer, in a patient. The methods comprise administering an effective amount of an Axl inhibitor in combination with the administration of an effective

Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position

Benzo[7]annulen-7-amines 7 without further polar substituents have been reported as conformationally restricted Ro 25-6981 analogs and show unexpectedly high GluN2B affinity. Herein the corresponding 2-NO2 derivatives 8 were synthesized and pharmacologically evaluated. NO2 derivatives 8 show 5- to 10-fold higher GluN2B affinity than the unsubstituted ligands 7. Docking studies of ligands 7c and 8c reveal an important contribution of the 2-NO2-substituent in determining the binding pose and modulating the GluN2B affinity.

POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS

Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases