741291-96-3Relevant articles and documents
New spirocyclic oxindole synthesis based on a hetero claisen rearrangement
Mao, Zhan,Baldwin, Steven W.
, p. 2425 - 2428 (2007/10/03)
(Equation Presented) A new method for preparing spirocyclic oxindoles is presented. Featuring a [3,3]-sigmatropic enolate rearrangement, the three-step process converts carboxylic acid starting materials to oxidnole products in overall yields of 52-76%. The enolate rearrangement step occurs at -78 °C and provides easy access to oxindole products that have previously been difficult to prepare.