74163-06-7

Basic information

• Product Name: (S)-2-[4-(2-{2-[(2,6-Diamino-5-nitro-pyrimidin-4-ylamino)-methyl]-[1,3]dioxolan-2-yl}-ethylsulfanyl)-benzoylamino]-pentanedioic acid diethyl ester
• Synonyms: (S)-2-[4-(2-{2-[(2,6-Diamino-5-nitro-pyrimidin-4-ylamino)-methyl]-[1,3]dioxolan-2-yl}-ethylsulfanyl)-benzoylamino]-pentanedioic acid diethyl ester
• CAS NO: 74163-06-7
• Molecular Weight: 621.671
• Mol File: 74163-06-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[4-(2-{2-[(2,6-Diamino-5-nitro-pyrimidin-4-ylamino)-methyl]-[1,3]dioxolan-2-yl}-ethylsulfanyl)-benzoylamino]-pentanedioic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[4-(2-{2-[(2,6-Diamino-5-nitro-pyrimidin-4-ylamino)-methyl]-[1,3]dioxolan-2-yl}-ethylsulfanyl)-benzoylamino]-pentanedioic acid diethyl ester(74163-06-7)
• EPA Substance Registry System: (S)-2-[4-(2-{2-[(2,6-Diamino-5-nitro-pyrimidin-4-ylamino)-methyl]-[1,3]dioxolan-2-yl}-ethylsulfanyl)-benzoylamino]-pentanedioic acid diethyl ester(74163-06-7)

Safety Data

• Hazardous Substances Data: 74163-06-7(Hazardous Substances Data)

Upstream product

• 74163-05-6 (S)-2-{4-[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoylamino}-pentanedioic acid diethyl ester 
• 6036-64-2 6-chloro-5-nitropyrimidine-2,4-diamine 
• 67426-03-3 1-chloro-4--2-butanone 
• 74162-96-2 1-azido-4--2-butanone 
• 74162-98-4 4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid 
• 74162-97-3 4-[2-(2-Azidomethyl-[1,3]dioxolan-2-yl)-ethylsulfanyl]-benzoic acid methyl ester 

Downstream Products

• 74163-10-3 11-thiohomoaminopterin 
• 74163-07-8 (S)-2-{4-[4-(2,6-Diamino-5-nitro-pyrimidin-4-ylamino)-3-oxo-butylsulfanyl]-benzoylamino}-pentanedioic acid diethyl ester 

Relevant articles and documents

Folate analogues altered in the C9-N10 bridge region. XVI. Synthesis and antifolate activity of 11-thiohomoaminopterin

The synthesis of 11-thiohomo-aminopterin (1), which is a close analogue of 11-thiohomofolic acid (2), has been carried out by modification of the Boon-Leigh procedure. Treatment of 1 chloro 4 [p(carbomethoxy)thiophenoxy] 2 butanone (5) with sodium azide g