741717-59-9

Basic information

• Product Name: [2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL
• Synonyms: [2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL;2-(1-Pyrazolyl)benzyl Alcohol
• CAS NO: 741717-59-9
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.2
• Mol File: 741717-59-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 129 °C
• Boiling Point: 338.3°C at 760 mmHg
• Flash Point: 158.4°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 3.86E-05mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: [2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL(741717-59-9)
• EPA Substance Registry System: [2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL(741717-59-9)

Safety Data

• Hazardous Substances Data: 741717-59-9(Hazardous Substances Data)

Usage

Description

[2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL is a chemical compound characterized by the molecular formula C11H10N2O. It features a phenyl group connected to a pyrazole ring, with a methanol group substituting one of the hydrogen atoms on the phenyl group. [2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL is recognized for its unique chemical properties and reactivity, making it a valuable component in various applications.

Uses

Used in Organic Synthesis:
[2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL is utilized as a building block in organic synthesis for the creation of a wide range of pharmaceuticals and other organic compounds. Its unique structure allows for the development of new molecules with potential applications across different industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, [2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL is used as a key component in the research and development of new drugs. Its chemical properties make it a promising candidate for the synthesis of innovative medicinal compounds that can address various health conditions.
Used in Academic Research:
[2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL is also employed in academic research settings, where it contributes to the study of biological processes and the exploration of new chemical reactions. Its unique reactivity and structure provide researchers with valuable insights into various scientific disciplines.
Used in Industrial Processes:
[2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL's distinctive chemical properties and reactivity make it suitable for use in industrial processes. [2-(1H-PYRAZOL-1-YL)PHENYL]METHANOL can be incorporated into the production of various products, enhancing their performance and functionality.

InChI:InChI=1/C10H10N2O/c13-8-9-4-1-2-5-10(9)12-7-3-6-11-12/h1-7,13H,8H2

Upstream product

• 400750-34-7 2-(1H-pyrazol-1-yl) benzoic acid methyl ester 
• 394-35-4 methyl 2-fluorobenzoate 
• 50-00-0 formaldehyd 
• 1126-00-7 1-phenylpyrazole 

Downstream Products

• 1026532-14-8 2-[2-(2-Pyrazol-1-yl-benzylsulfanyl)-imidazol-1-yl]-pyridine 
• 138479-47-7 2-(1H-pyrazol-1-yl)benzaldehyde 

Relevant articles and documents

Ru-Catalyzed Regioselective Direct Hydroxymethylation of (Hetero)Arenes via C-H Activation

An efficient and direct ruthenium-catalyzed regioselective hydroxymethylation of (hetero)arenes via C-H activation with paraformaldehyde as a hydroxymethylating reagent is described. The corresponding products can be obtained in good to excellent yield. A number of aryl aldehydes can also be used in place of paraformaldehyde giving the desired alcohol products with similarly good results.

2-[(2-Aminobenzyl)sulfinyl]-1-(2-pyridyl)-1,4,5,6- tetrahydrocyclopent[d]imidazoles as a novel class of gastric H+/K+-ATPase inhibitors

Substituted 2-sulfinylimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase. The 4,5-unsubstituted imidazole series 6-11 and the 1,4,5,6-tetrahydrocyclopent[d]imidazole series 12 were found to be potent inhibitors of the acid secretory enzyme H+/K+- ATPase. Structure-activity relationships indicate that the substitution of 2- pyridyl groups at the 1-position of the imidazole moiety combined with (2- aminobenzyl)sulfinyl groups at the 2-position leads to highly active compounds with a favorable chemical stability. Other substitution patterns in the imidazole moiety result in reducing biological activities. 2-[(2- Aminobenzyl)sulfinyl]-1-[2-(3-methylpyridyl)]-1,4,5,6- tetrahydrocyclopent[d]imidazole (12h, T-776) was selected for further development as a potential clinical candidate. Extensive study on the acid degradation of 12h indicates a mechanism of action different from that of omeprazole, the first H+/K+-ATPase inhibitor introduced to the market.