742062-68-6Relevant articles and documents
A convenient procedure for the synthesis of 3-substituted 5,6-dihydro-4H-1,2-oxazines from nitroethane
Sukhorukov, Alexey Yu.,Klenov, Michael S.,Ivashkin, Pavel E.,Lesiv, Alexey V.,Khomutova, Yulya A.,Ioffe, Sema L.
, p. 97 - 107 (2007)
A novel and efficient four-step procedure for the synthesis of C-3-functionalised 5,6-dihydro-4H-1,2-oxazines from nitroethane is described. It includes preparation of 3-methyl-substituted six-membered cyclic nitronates, 3-(bromomethyl)-substituted 5,6-dihydro-4H-1,2-oxazines as intermediates, and nucleophilic substitution of bromine. Total yields of the target C-3-functionalised oxazines are 15-30% from nitroethane. Georg Thieme Verlag Stuttgart.
