742085-70-7

Basic information

• Product Name: (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone
• Synonyms: (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone;5-Bromo-2-(pyrrolidin-1-ylcarbonyl)pyridine;1-(5-Bromopyridin-2-ylcarbonyl)pyrrolidine;5-Bromo-2-(pyrrolindin-1-ylcarbonyl)pyridine
• CAS NO: 742085-70-7
• Molecular Formula: C₁₀H₁₁BrN₂O
• Molecular Weight: 255.11
• Product Categories: blocks;Bromides;Carboxes;Pyridines
• Mol File: 742085-70-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 377.8ºC at 760 mmHg
• Flash Point: 182.3ºC
• Appearance: /
• Density: 1.534g/cm3
• Vapor Pressure: 6.59E-06mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone(742085-70-7)
• EPA Substance Registry System: (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone(742085-70-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 742085-70-7(Hazardous Substances Data)

Usage

General Description

(5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone is a chemical compound that consists of a pyridine ring with a bromine atom in the 5 position, and a pyrrolidin-1-yl group attached to a methanone moiety. (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone is commonly used in the field of medicinal chemistry for the synthesis of various pharmaceuticals and biologically active molecules. It has been found to exhibit a wide range of pharmacological activities, including antiviral, antibacterial, and antifungal properties. Additionally, it has shown potential as an intermediate in the preparation of diverse chemical substances, making it a valuable building block for the production of new compounds. Overall, (5-Bromopyridin-2-yl)(pyrrolidin-1-yl)methanone is a versatile and important chemical in the pharmaceutical and chemical industries.

InChI:InChI=1/C10H11BrN2O/c11-8-3-4-9(12-7-8)10(14)13-5-1-2-6-13/h3-4,7H,1-2,5-6H2

Upstream product

• 123-75-1 pyrrolidine 
• 624-28-2 2,5-dibromopyridine 
• 201230-82-2 carbon monoxide 
• 137178-88-2 5-bromopyridine-2-carbonyl chloride 
• 30766-11-1 5-bromoisonicotinic acid 

Downstream Products

• 940314-18-1 2-(pyrrolidin-1-ylcarbonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 

Relevant articles and documents

A thiophene and pyrimidine derivatives, its preparation process and its use in medicine

The invention discloses thiophene miazines derivates as well as a preparation method and a medical application thereof. The thiophene miazines derivates are compounds with a general formula I, a general formula II or a general formula III, wherein in the general formulae, Ar is any one of phenyl, halogen-substituted phenyl, C1-6 alkyl-substituted phenyl, biphenylyl, halogen-substituted biphenylyl, naphthyl, pyridyl, thienyl, halogen-substituted thienyl, C1-3 alkyl-substituted thienyl, furyl, halogen-substituted furyl and C1-3 alkyl-substituted furyl, A, D and E are respectively carbon atoms or nitrogen atoms but are not carbon atoms at the same time, and R is R1-NH-. The thiophene miazines derivates provided by the invention can be used for obviously restraining the activity of an EGFR (Epidermal Growth Factor Receptor) and the activity of A431 cells, are expected to be developed as a tyrosine kinase inhibitor, and are extensive in application prospect and medicinal value.

HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES

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AMINE DERIVATIVE

The present invention provides a compound represented by the formula wherein Ar1 is a cyclic group optionally having substituent(s); R is a hydrogen atom, an optionally halogenated C1-6 alkyl, a phenyl optionally having substituent(s