74209-34-0

Basic information

• Product Name: 3-BROMO-7-NITROINDAZOLE
• Synonyms: 3-BroMo-7-nitro-1H-indazo...;1H-INDAZOLE,3-BROMO-7-NITRO-;BRNI;7-NITROINDAZOLE, 3-BROMO-;3-BROMO-7-NITROINDAZOLE;3-BROMO-7-NITRO-1H-INDAZOLE;3-Bromo-7-nitroindazole, 98+%
• CAS NO: 74209-34-0
• Molecular Formula: C₇H₄BrN₃O₂
• Molecular Weight: 242.03
• Product Categories: Nitric Oxide Synthase (iNOS)Enzyme Inhibitors by Enzyme;Nitric Oxide Synthase neuronalNitric Oxide and Cell Stress;Enzyme Inhibitors by Enzyme;L to;Nitric Oxide Metabolism;Nitric Oxide Synthase RegulatorsCell Signaling Enzymes;NOS Inhibitors;Nitric Oxide;Indoles and derivatives;All Inhibitors;Inhibitors;Nitric Oxide Reagents
• Mol File: 74209-34-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 175-185 °C
• Boiling Point: 182°C
• Flash Point: 104.3 °C
• Appearance: light yellow/powder
• Density: 1.8856 (rough estimate)
• Vapor Pressure: 0.033mmHg at 25°C
• Refractive Index: 1.6200 (estimate)
• Storage Temp.: 2-8°C
• Solubility: ethanol: 25 mg/mL
• PKA: 7.85±0.40(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 3-BROMO-7-NITROINDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-7-NITROINDAZOLE(74209-34-0)
• EPA Substance Registry System: 3-BROMO-7-NITROINDAZOLE(74209-34-0)

Safety Data

• Hazard Codes: T
• Statements: 60
• Safety Statements: 53-22-36/37/39-45
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 74209-34-0(Hazardous Substances Data)

Usage

Description

3-Bromo-7-nitroindazole is a chemical compound that acts as a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). It is characterized by the presence of a bromine atom at the 3rd position and a nitro group at the 7th position on the indazole ring. 3-BROMO-7-NITROINDAZOLE has been found to be a more effective inhibitor of rat cerebellar nitric oxide synthase than 7-nitroindazole.

Uses

Used in Pharmaceutical Industry:
3-Bromo-7-nitroindazole is used as a research chemical for studying the role of nitric oxide synthase (NOS) in various biological processes. Its potent and selective inhibition of nNOS makes it a valuable tool in understanding the function of this enzyme in the nervous system.
Used in Neuroscience Research:
3-Bromo-7-nitroindazole is used as a neuroprotective compound in neuroscience research. It has been found to inhibit the endoplasmic reticulum stress pathway, which is implicated in various neurodegenerative diseases. This property makes it a potential candidate for the development of therapeutic agents targeting neurodegenerative disorders.
Used in Cognitive Function Studies:
3-Bromo-7-nitroindazole is used as a research tool to investigate the role of nNOS in spatial memory formation in rats. By inhibiting the activity of nNOS, researchers can gain insights into the mechanisms underlying cognitive functions and memory processes.

InChI:InChI=1/C7H4BrIN2/c8-7-4-2-1-3-5(9)6(4)10-11-7/h1-3H,(H,10,11)

Upstream product

• 101860-76-8 1-acetyl-7-nitro-1H-indazole 
• 2942-42-9 7-Nitroindazole 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 570-24-1 2-Methyl-6-nitroaniline 

Downstream Products

• 316810-90-9 3-bromo-1H-indazol-7-amine 
• 74209-37-3 3-bromo-1-methyl-7-nitro-1H-indazole 
• 74209-39-5 3-bromo-2-methyl-7-nitro-2H-indazole 
• 1610362-72-5 1-(4-methoxybenzyl)-7-nitro-3-phenyl-1H-indazole 
• 1610362-73-6 1-(4-methoxybenzyl)-3-phenyl-1H-indazol-7-amine 
• 1610362-74-7 phenyl (1-(4-methoxybenzyl)-3-phenyl-1H-indazol-7-yl)carbamate 
• 1610362-71-4 3-bromo-1-(4-methoxybenzyl)-7-nitro-1H-indazole 

Relevant articles and documents

New and efficient synthesis of bi- and trisubstituted indazoles

In this paper, the synthesis of bi- and trisubstituted indazoles was described. 4-Alkoxy-7-aminoprotected-indazole or 7-aminoprotected-indazole derivatives were prepared selectively using SnCl2 in alcohol or SnCl2 in ethyl acetate, r