74209-51-1Relevant articles and documents
Synthesis and Antibacterial Activity of Novel 4″-O-desosaminyl clarithromycin derivatives with 11, 12-arylalkyl side chains
Zhao, Zhe-Hui,Zhu, Di,Zhang, Xiao-Xi,Luo, Zhi-Gang,Lei, Ping-Sheng
, p. 1 - 9 (2018/04/24)
A series of novel 4″-O-desosaminyl clarithromycin derivatives with 11, 12-arylalkyl side chains was synthesized by coupling 6-deoxy-desosamine donors (18, 19) with 4″-OH of compounds 5a–c. The activities of the target compounds were tested against a series of macrolide-sensitive and macrolide-resistant pathogens. Some of them showed activities against macrolide sensitive and resistant pathogens, and compounds 21d and 21e displayed significant improvement of activities against resistant pathogens.
Efficient synthesis of 2-imidazol-2-ylacetates
Ha, Jae Du,Lee, Su Jung,Nam, So Yeun,Kang, Seung Kyu,Cho, Seung Yoon,Ahn, Jin Hee,Choi, Joong-Kwon
, p. 6201 - 6204 (2007/10/03)
A simple method of synthesizing various 2-imidazol-2-ylacetates is described. Condensation of α-aminoketals with imidates, followed by cyclization in refluxing 4 M-HCl/Dioxane, yielded 2-imidazol-2-ylacetates under one-pot and mild reaction conditions.
Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides and uses thereof
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Page/Page column 195, (2010/01/31)
γ-Hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamide compounds are inhibitors of HIV protease and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.