74226-89-4

Basic information

• Product Name: 2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-5-guanidino-pentanoic acid sec-butyl ester; compound with toluene-4-sulfonic acid
• CAS NO: 74226-89-4
• Molecular Weight: 808.011
• Mol File: 74226-89-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-5-guanidino-pentanoic acid sec-butyl ester; compound with toluene-4-sulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-5-guanidino-pentanoic acid sec-butyl ester; compound with toluene-4-sulfonic acid(74226-89-4)
• EPA Substance Registry System: 2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-5-guanidino-pentanoic acid sec-butyl ester; compound with toluene-4-sulfonic acid(74226-89-4)

Safety Data

• Hazardous Substances Data: 74226-89-4(Hazardous Substances Data)

Upstream product

• 74-79-3 L-arginine 
• 605-65-2 5-(dimethylamino)naphth-1-ylsulfonyl chloride 
• 104-15-4 toluene-4-sulfonic acid 
• 4307-78-2 N^α-dansyl-L-arginine 
• 78-92-2 iso-butanol 

Relevant articles and documents

Thrombin inhibitors. I. Ester derivatives of N(α)-(arylsulfonyl)-L-arginine

A series of N(α)(arylsulfonyl)-L-arginine esters was prepared and tested as inhibitors of the clotting activity of thrombin. N (α)Dansyl-L-arginine methyl ester was the most inhibitory of the N (α)(arylsulfonyl)-L-arginine methyl esters. The most potent inhibitors were the n-propyl and n-propyl esters of N(α)-dansyl-L-arginine with an I(50) of 2 x 10(-6) M. Esters of unsaturated straight-chain alcohols with a chain length of four carbons were also as inhibitory as the n-butyl ester. The inhibitors were hydrolyzed by thrombin and trypsin more slowly than N (α)-tosyl-L-arginine methyl ester.