74248-66-1

Basic information

• Product Name: Benzoic acid, 4-(3-oxobutyl)-
• CAS NO: 74248-66-1
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Mol File: 74248-66-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(3-oxobutyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(3-oxobutyl)-(74248-66-1)
• EPA Substance Registry System: Benzoic acid, 4-(3-oxobutyl)-(74248-66-1)

Safety Data

• Hazardous Substances Data: 74248-66-1(Hazardous Substances Data)

Upstream product

• 6232-88-8 4-bromomethylbenzoic Acid 
• 74248-99-0 methyl 2-(4-methoxycarbonylphenyl)ethyl ketone 
• 187242-82-6 (E)-4-(3-oxobut-1-en-1-yl)benzoic acid 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 115665-93-5 (E)-methyl 4-(3-oxobut-1-en-1-yl)benzoate 
• 619-66-9 4-Carboxybenzaldehyde 
• 398472-14-5 4-(5methoxy-1H-benzimidazol-2-yl-sulfanylmethyl)-benzoic acid 
• 124-38-9 carbon dioxide 
• 181214-91-5 4-((E)-3-Oxo-but-1-enyl)-benzoic acid 

Downstream Products

• 1019770-00-3 4-(3-oxobutyl)benzoyl chloride 
• 74248-67-2 4-(4-aminocarbonylphenyl)-2-butanone 
• 1019769-98-2 4-(3-oxobutyl)-N-(2,2,2-trifluoroethyl)benzamide 
• 74248-99-0 methyl 2-(4-methoxycarbonylphenyl)ethyl ketone 
• 1019770-04-7 N-cyclopropyl-4-(3-oxobutyl)benzamide 

Relevant articles and documents

Shuttle arylation by Rh(I) catalyzed reversible carbon–carbon bond activation of unstrained alcohols

The advent of transfer hydrogenation and borrowing hydrogen reactions paved the way to manipulate simple alcohols in previously unthinkable manners and circumvented the need for hydrogen gas. Analogously, transfer hydrocarbylation could greatly increase the versatility of tertiary alcohols. However, this reaction remains unexplored because of the challenges associated with the catalytic cleavage of unactivated C–C bonds. Herein, we report a rhodium(I)-catalyzed shuttle arylation cleaving the C(sp2)–C(sp3) bond in unstrained triaryl alcohols via a redox-neutral β-carbon elimination mechanism. A selective transfer hydrocarbylation of substituted (hetero)aryl groups from tertiary alcohols to ketones was realized, employing benign alcohols as latent C-nucleophiles. All preliminary mechanistic experiments support a reversible β-carbon elimination/migratory insertion mechanism. In a broader context, this novel reactivity offers a new platform for the manipulation of tertiary alcohols in catalysis.

INDAZOLE DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS

The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for e

Rhodium(I)-catalyzed carboxylation of aryl- and alkenylboronic esters with CO2

When the esters of arylboronic acids with 2,2-dimethylpropan-1,3-diol were treated with a catalytic amount of [Rh(OH)(cod)]2 in the presence of 1,3-bis(diphenylphosphino)propane and CsF in dioxane at 60 °C under carbon dioxide atmosphere, the benzoic acid derivatives were obtained in good yields. Reactions of alkenylboronic esters also proceeded under similar conditions to give α,β-unsaturated carboxylic acids. As these boronic esters are now easily available through coupling or direct borylation reactions, this method would be a useful method for the preparation of various functionalized aryl- and alkenyl-carboxylic acids. Copyright