74254-54-9Relevant articles and documents
Synthesis of the 2-ethyl-3-methylsuccinic acids via a stereospecific malonic ester alkylation
Leeuwen, F. F. van,Noordam, A.,Maat, L.,Beyerman, H. C.
, p. 96 - 99 (2007/10/02)
Reaction of (-)-(S)-methyl 2-bromopropionate (4) (obtained from L-alanine) with dibenzyl ethylmalonate gave stereospecifically in four steps (+)-(2R,3S)-2-ethyl-3-methylsuccinic acid (8a) and its diastereoisomer (8b).The malonic ester alkylation proceeded with Walden inversion.The chiroptical properties of the acids and the intermediates are in conformity with the known absolute configurations.