74257-99-1

Basic information

• Product Name: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl]-, phenylmethyl ester
• CAS NO: 74257-99-1
• Molecular Formula: C23H34N2O5
• Molecular Weight: 418.533
• Mol File: 74257-99-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl]-, phenylmethyl ester(74257-99-1)
• EPA Substance Registry System: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl]-, phenylmethyl ester(74257-99-1)

Safety Data

• Hazardous Substances Data: 74257-99-1(Hazardous Substances Data)

Upstream product

• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 41324-66-7 H-Pro-OBzl 

Downstream Products

• 41324-69-0 N-(tert-butoxycarbonyl)-L-isoleucyl-L-proline 

Relevant articles and documents

Synthesis method of amide nitrogen trifluoromethyl compound

The invention discloses a synthesis method of an amide nitrogen trifluoromethyl compound. The synthesis method comprises the following step: carrying out trifluoromethylation reaction on a compound shown in a formula a1 or a formula a2 and a trifluoromethylation reagent in an organic solvent under the action of a fluorination reagent, an oxidant, silver oxysalt and a pyridine ligand, so as to obtain a target compound shown in a formula b1 or a formula b2. According to the invention, trifluoromethylation reaction can be directly carried out on an amide compound shown as a formula a1 or a sulfonamide compound shown as a formula a2 so as to obtain the amide nitrogen trifluoromethyl compound shown in the formula b1 or the sulfamide nitrogen trifluoromethyl compound shown in the formula b2. Themethod has the advantages of simple operation, easily available raw materials, low cost, safety, environmental protection, mild reaction conditions, easy realization of large-scale production, and the like, and is of great significance to the industrial application of the amide nitrogen trifluoromethyl compound.

HISTONE DEACETYLASE INHIBITOR AND PROCESS FOR PRODUCING THE SAME

HDAC inhibitors represented by formula (1) show strong inhibitory activity against various subtypes of HDACs. The compounds of the present invention find utility as pharmaceutical agents for treating or preventing diseases associated with HDAC 1, 4, and 6

Cyclic Tetrapeptides Bearing a Sulfhydryl Group Potently Inhibit Histone Deacetylases

(Equation presented) New inhibitors of histone deacetylase (HDAC) containing a sulfhydryl group were designed on the basis of the corresponding hydroxamic acid (CHAP31) and FK228. Their disulfide dimers and hybrids exhibited potent HDAC inhibitory activity in vivo with potential as anticancer prodrugs.