74290-65-6

Basic information

• Product Name: 2-Amino-3-bromo-5-methylpyrazine
• Synonyms: 2-Amino-3-bromo-5-methylpyrazine;3-Bromo-5-methylpyrazin-2-ylamine;3-bromo-5-methylpyrazin-2-amine;3-broMo-5-Methylpyrazin-2-Mine;2-PyrazinaMine, 3-broMo-5-Methyl-
• CAS NO: 74290-65-6
• Molecular Formula: C₅H₆BrN₃
• Molecular Weight: 188.02524
• Product Categories: Halides;Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 74290-65-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 56-57 °C
• Boiling Point: 275.005 °C at 760 mmHg
• Flash Point: 120.119 °C
• Appearance: /
• Density: 1.7 g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.65±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-3-bromo-5-methylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-bromo-5-methylpyrazine(74290-65-6)
• EPA Substance Registry System: 2-Amino-3-bromo-5-methylpyrazine(74290-65-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 74290-65-6(Hazardous Substances Data)

Usage

General Description

2-Amino-3-bromo-5-methylpyrazine is a chemical compound with the formula C5H6BrN3. It is a derivative of pyrazine, which is a six-membered aromatic heterocycle with two nitrogen atoms at positions 1 and 4. 2-Amino-3-bromo-5-methylpyrazine is a pale yellow to brown crystalline solid that is sparingly soluble in water. 2-Amino-3-bromo-5-methylpyrazine is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, and it can also be used as a building block to create other organic compounds. Additionally, it can be used as a flavor and fragrance ingredient in food and cosmetic products.

InChI:InChI=1/C5H6BrN3/c1-3-2-8-5(7)4(6)9-3/h2H,1H3,(H2,7,8)

Upstream product

• 5521-58-4 5-methylpyrazin-2-amine 

Downstream Products

• 5521-58-4 5-methylpyrazin-2-amine 
• 17890-82-3 3-amino-6-methylpyrazine-2-carbonitrile 

Relevant articles and documents

Heterocyclic compound as well as pharmaceutical composition, preparation method, intermediate and application thereof

The invention discloses a heterocyclic compound as well as a pharmaceutical composition, a preparation method, an intermediate and application thereof. The structure of the heterocyclic compound is shown as a formula I, and the heterocyclic compound has CDK7 inhibitory activity and can be used for treating diseases such as tumors.

BICYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS

The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders.