74316-52-2Relevant articles and documents
CXCR4-ANTAGONISTIC DRUGS COMPRISING NITROGEN-CONTAINING COMPOUND
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Page/Page column 102, (2010/02/05)
To provide novel nitrogen-containing compounds having antagonism to CXCR4 and remedies for disease, such as rheumatism, cancer metastasis, etc., based on the CXCR4 antagonism. Nitrogen-containing compounds represented by the following general formula and
SYNTHESIS AND BROMINATION OF 8-METHYLQUINOLINE-5-CARBOXYLIC ACID
Gracheva, I.N.,Tochilkin, A.I.
, p. 275 - 277 (2007/10/02)
8-Methylquinoline-5-carboxylic acid was obtained by the Skraup reaction from 3-amino-p-toluic acid or by hydrolysis of 5-cyano-8-methylquinoline.The latter was synthesized by the Rosemund-von Braun reaction from 5-bromo-8-methylquinoline, which was obtained by bromination of 8-methylquinoline in the presence of silver sulfate.Bromination in the side chain of 8-methylquinoline-5-carboxylic acid and its nitrile was studied.