7432-60-2

Basic information

• Product Name: DIETHYL-(2-HYDROXYCYCLOHEXYL)-AMINE
• Synonyms: DIETHYL-(2-HYDROXYCYCLOHEXYL)-AMINE
• CAS NO: 7432-60-2
• Molecular Formula: C₁₀H₂₁NO
• Molecular Weight: 171.28
• Mol File: 7432-60-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DIETHYL-(2-HYDROXYCYCLOHEXYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL-(2-HYDROXYCYCLOHEXYL)-AMINE(7432-60-2)
• EPA Substance Registry System: DIETHYL-(2-HYDROXYCYCLOHEXYL)-AMINE(7432-60-2)

Safety Data

• Hazardous Substances Data: 7432-60-2(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 93285-88-2 (+/-)-trans-2-ethylamino-cyclohexanol 
• 286-20-4 cyclohexane-1,2-epoxide 
• 109-89-7 diethylamine 
• 6628-80-4 trans-2-chlorocyclohexanol 
• 71-36-3 butan-1-ol 
• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 80-40-0 ethyl ester of p-toluenesulfonic acid 
• 286-20-4 cyclohexene oxide 
• 125582-78-7 C₁₀H₂₅NPb 

Downstream Products

• 103156-41-8 (+/-)-3,4,5-trimethoxy-benzoic acid-(trans-2-diethylamino-cyclohexyl ester) 
• 109067-64-3 (+/-)-2-methoxy-benzoic acid-(trans-2-diethylamino-cyclohexyl ester) 
• 30721-82-5 (+/-)-4-amino-benzoic acid-(trans-2-diethylamino-cyclohexyl ester) 

Relevant articles and documents

Syntheses, structures and catalytic activities of low-coordinated rare-earth metal complexes containing 2,2′-pyridylpyrrolides

Reactions of the ligand precursors 2-(2′-pyridyl)-3,5-Me2-pyrrole (L1H) and 2-(2-pyridyl)-3,4,5-Me3-pyrrole (L2H) with [(Me3Si)2N]3RE(μ-Cl)Li(THF)3 in toluene afforded a series of low-coordinated rare-earth metal bis-amido complexes L1RE[N(SiMe3)2]2 [RE = Y (1a), Dy (1b), Er (1c), Yb (1d)] and L2RE[N(SiMe3)2]2 [RE = Y (2a), Dy (2b), Er (2c), Yb (2d)]. With the ionic radius of rare-earth metal increasing, the reaction of L1H and [(Me3Si)2N]3RE(μ-Cl)Li(THF)3 gave dinuclear complexes (L1)2RE(μ-Cl)(μ-η5:η1:η1-L1)RE(L1)[N(SiMe3)2]2 [RE = Sm (1e), Pr (1f)]; however, the reaction of L2H and [(Me3Si)2N]3Sm(μ-Cl)Li(THF)3 afforded (L2)2Sm[N(SiMe3)2]2 (2e). Results indicated that the ionic radius of rare-earth metal and subtle change in the ligands have substantial effects on the structure and bonding mode of complexes. The complexes showed a high catalytic activity for the ring-opening reaction of cyclohexene oxide with amines to afford various β-aminoalcohols under mild solvent-free conditions.

Tetragonal versus hexagonal: Structure-dependent catalytic activity of Co/Zn bimetallic metal-organic frameworks

Tetragonal and hexagonal phases of monometallic Zn and bimetallic Co/Zn metal-organic frameworks (MOFs), with secondary building units (SBUs) containing a M3O (M = metal) cluster, were synthesized from identical constituents using a benzenetricarboxylate (BTC3-) linker that forms decorated 3,6- and 3,5-connected networks, respectively. There exist subtle differences between the SBUs; one of the metal atoms in the M3O cluster in the tetragonal phase has one dissociable DMF solvent molecule while that in the hexagonal phase has three. Connectivities between the SBUs form one-dimensional channels in both MOFs. These MOFs catalyze the chemoselective addition of amines to epoxides, giving exclusively β-hydroxyamine under heterogeneous conditions. A ring-opening reaction of a symmetrical epoxide showed that the hexagonal phase diastereoselectively yields trans-alcohol, exhibiting an exquisite model for structure-dependent activity.

Highly chemoselective addition of amines to epoxides in water

(Chemical Equation Presented) Aminolysis of a variety of epoxides by aliphatic and aromatic amines in water, in the absence of any catalyst with high yields, is reported. β-Amino alcohols were formed under mild conditions with high selectivity and in excellent yields.