74331-99-0

Basic information

• Product Name: Acetamide, N-(3,4-dioxo-1,5-cyclohexadien-1-yl)-
• CAS NO: 74331-99-0
• Molecular Formula: C8H7NO3
• Molecular Weight: 165.148
• Mol File: 74331-99-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(3,4-dioxo-1,5-cyclohexadien-1-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(3,4-dioxo-1,5-cyclohexadien-1-yl)-(74331-99-0)
• EPA Substance Registry System: Acetamide, N-(3,4-dioxo-1,5-cyclohexadien-1-yl)-(74331-99-0)

Safety Data

• Hazardous Substances Data: 74331-99-0(Hazardous Substances Data)

Upstream product

• 103-90-2 4-acetaminophenol 
• 74332-02-8 4-N-acetylamino-1,2-benzenediol diacetate 
• 37519-14-5 3-Hydroxyacetaminophen 

Downstream Products

• 636-25-9 diamino-2,5 phenol 
• 135-67-1 phenoxazine 
• 258-72-0 triphenodioxazine 
• 21086-81-7 2,5-Bis(phenylamino)-4-phenylimino-2,5-cyclohexadienone 

Relevant articles and documents

Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy

Prodrug activation, by exogenously administered enzymes, for cancer therapy is an approach to achieve better selectivity and less systemic toxicity than conventional chemotherapy. However, the short half-lives of the activating enzymes in the bloodstream has limited its success. Demonstrated here is that a tyrosinase-MOF nanoreactor activates the prodrug paracetamol in cancer cells in a long-lasting manner. By generating reactive oxygen species (ROS) and depleting glutathione (GSH), the product of the enzymatic conversion of paracetamol is toxic to drug-resistant cancer cells. Tyrosinase-MOF nanoreactors cause significant cell death in the presence of paracetamol for up to three days after being internalized by cells, while free enzymes totally lose activity in a few hours. Thus, enzyme-MOF nanocomposites are envisioned to be novel persistent platforms for various biomedical applications.