743434-15-3Relevant articles and documents
Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core
Shen, Dong-Ming,Brady, Edward J.,Candelore, Mari R.,Dallas-Yang, Qing,Ding, Victor D.-H.,Feeney, William P.,Jiang, Guoquiang,McCann, Margaret E.,Mock, Steve,Qureshi, Sajjad A.,Saperstein, Richard,Shen, Xiaolan,Tong, Xinchun,Tota, Laurie M.,Wright, Michael J.,Yang, Xiaodong,Zheng, Song,Chapman, Kevin T.,Zhang, Bei B.,Tata, James R.,Parmee, Emma R.
scheme or table, p. 76 - 81 (2011/02/27)
A novel class of 1,3,5-pyrazoles has been discovered as potent human glucagon receptor antagonists. Notably, compound 26 is orally bioavailable in several preclinical species and shows selectivity towards cardiac ion channels, other family B receptors suc
