743460-48-2 Usage
Description
Biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester, also known as revefenacin, is a long-acting muscarinic antagonist (LAMA) with bronchodilator properties. It is a complex organic compound that belongs to the carbamic acid ester class and is characterized by its biphenyl and piperidine structural elements. biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester is known for its ability to block muscarinic receptors in the airways, leading to the relaxation of smooth muscles and improved lung function.
Uses
Used in Pharmaceutical Industry:
Biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester is used as an active pharmaceutical ingredient (API) for the development of revefenacin and its salts. It is specifically utilized for the treatment of chronic obstructive pulmonary disease (COPD), a group of lung diseases that cause airflow blockage and breathing-related problems. As a LAMA, revefenacin helps to reduce symptoms such as shortness of breath, wheezing, and coughing by relaxing the airway muscles and improving lung function.
Additionally, revefenacin may be used in combination with other medications, such as long-acting beta2-agonists (LABAs), to provide a dual bronchodilator therapy for patients with moderate to severe COPD. This combination can offer enhanced symptom relief and improved lung function compared to monotherapy.
Check Digit Verification of cas no
The CAS Registry Mumber 743460-48-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,3,4,6 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 743460-48:
(8*7)+(7*4)+(6*3)+(5*4)+(4*6)+(3*0)+(2*4)+(1*8)=162
162 % 10 = 2
So 743460-48-2 is a valid CAS Registry Number.
743460-48-2Relevant articles and documents
Preparation method of remifenfloxacin intermediate
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Paragraph 0049-0053, (2021/10/30)
The invention discloses a preparation method of a remifenfloxacin intermediate, belongs to the technical field of drug synthesis, and solves the problems of long synthesis route, environmental unfriendliness, harsh reaction conditions and low yield of a remifenfloxacin key intermediate in the prior art. The preparation method of the remifenfloxacin intermediate as shown in the formula I comprises the following steps: reacting a compound as shown in a formula II with a compound as shown in a formula III or a salt thereof to generate a compound as shown in the formula I; the reaction formula is shown in the specification; and wherein X is halogen. The method is simple, easy and convenient to operate, short in route, high in yield, free of toxic oxidizing agents and catalytic hydrogenation, environmentally friendly and easier to industrialize, and only one step is needed.
Preparation methods of revefenacin intermediate and revefenacin
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Paragraph 0055-0059, (2021/05/26)
The invention relates to a synthesis method of a revefenacin intermediate, which specifically comprises the following steps: in a solvent, enabling piperidin-4-yl [1,1-biphenyl]-2-carbamate to react with methyl(2-oxyethyl) tert-butyl carbamate in the pres
PROCESS FOR PREPARING A BIPHENYL-2-YLCARBAMIC ACID
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, (2012/02/01)
The invention provides a process of preparing an intermediate useful in the synthesis of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester, and a process of preparing a crystalline freebase of the ester.
