7438-46-2Relevant articles and documents
Sensitive spectrophotometric method for determination of some phenothiazine drugs
Upadhyay, Kanchan,Asthana, Anupama,Tamrakar, Raunak Kumar
, p. 7481 - 7495 (2015/02/19)
A new simple and sensitive spectrophotometric method for some phenothiazine derivatives has been developed. The proposed method is based on the reaction of phenothiazine derivatives promethazine hydrochloride, chlorpromazine hydrochloride, triflupromazine hydrochloride, prochlorperazine, and trifluoperazine with potassium iodate followed by reaction of liberated iodine with leuco crystal violet (LCV) and measurement of the color of the oxidized LCV at 598 nm. The method showed a good linearity in the ranges 0.05-4.0, 0.02-2.0, 0.05-5.0, 0.1-8.0, and 0.05-2.0 μg mL-1 respectively. The optimum conditions and other analytical parameters were evaluated. The proposed methods have been applied successfully to the analysis of phenothiazine derivatives in pure form and in their dosage forms, and no interference was observed from common excipients present in pharmaceutical formulations.
MECHANISM OF THE HYDRIDE TRANSFER REACTION OF LEUCO CRYSTAL VIOLET WITH CYANOMETHYLENE ACCEPTORS
Nishimura, Norio,Zaman, Khan M.,Yamamoto, Shunzo
, p. 218 - 220 (2007/10/02)
In the hydride transfer reaction of Leuco Crystal Violet to form the Crystal Violet cation, the role of cyanomethylene acceptors was found to be essentially different from that of p-benzoquinones, both previously believed to act as ?-acceptors in the same manner.
KINETIC ISOTOPE AND PRESSURE EFFECTS IN THE REACTION OF LEUCOCRYSTAL VIOLET WITH TETRACYANOETHYLENE AND CHLORANIL.
Nishimura,Motoyama
, p. 1 - 7 (2007/10/02)
The rates of reaction of Leucocrystal Violet (LCV) with chloranil (CA) and tetracyanoethylene (TCNE) were measured, and the kinetic isotope and pressure effects were examined. In the LCV-CA system, a very large isotope effect was observed, while in the LCV-TCNE system, it was not so large (k//H/k//D equals 5-6) suggesting the tunnel effect is not substantial. For both systems, the formation of a CT complex in equilibrium with the reactants was observed at low temperatures ( less than minus 50 degree C). From the rate law, the isotope effect, the electronic and ESR spectra observed during the reaction, and their time dependence, possible reaction processes are proposed.