74405-42-8 Usage
Description
5'-O-(4,4'-DIMETHOXYTRITYL)-N6-BENZOYL-2'-DEOXYADENOSINE-3'-O-SUCCINIC ACID, also known as N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-O-succinate, is a protected adenosine derivative that plays a crucial role in the synthesis of nucleic acids and specialized compounds. It is characterized by its ability to protect the adenosine molecule during chemical reactions, ensuring the successful formation of the desired products.
Uses
Used in Pharmaceutical Industry:
5'-O-(4,4'-DIMETHOXYTRITYL)-N6-BENZOYL-2'-DEOXYADENOSINE-3'-O-SUCCINIC ACID is used as a key intermediate in the synthesis of nucleic acids for the development of new drugs and therapies. Its protective properties ensure the stability and integrity of the adenosine molecule during the synthesis process, leading to more effective and targeted treatments.
Used in the Synthesis of Specialized Compounds:
In the field of chemical research and development, 5'-O-(4,4'-DIMETHOXYTRITYL)-N6-BENZOYL-2'-DEOXYADENOSINE-3'-O-SUCCINIC ACID is used as a building block for the creation of specialized compounds, such as dinucleoside phosphorothioate prodrugs. These prodrugs have potential applications in the treatment of various diseases, including hepatitis B virus (HBV) infections, due to their enhanced oral bioavailability and targeted action.
Used in the Development of Anti-HBV Agents:
5'-O-(4,4'-DIMETHOXYTRITYL)-N6-BENZOYL-2'-DEOXYADENOSINE-3'-O-SUCCINIC ACID is used as a starting material in the development of anti-HBV agents, specifically dinucleoside phosphorothioate prodrugs. These prodrugs have shown promise in treating HBV infections due to their improved oral bioavailability and targeted delivery to the affected cells, leading to more effective treatment outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 74405-42-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,4,0 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 74405-42:
(7*7)+(6*4)+(5*4)+(4*0)+(3*5)+(2*4)+(1*2)=118
118 % 10 = 8
So 74405-42-8 is a valid CAS Registry Number.
InChI:InChI=1/C42H39N5O9/c1-52-31-17-13-29(14-18-31)42(28-11-7-4-8-12-28,30-15-19-32(53-2)20-16-30)54-24-34-33(56-37(50)22-21-36(48)49)23-35(55-34)47-26-45-38-39(43-25-44-40(38)47)46-41(51)27-9-5-3-6-10-27/h3-20,25-26,33-35H,21-24H2,1-2H3,(H,48,49)(H,43,44,46,51)/t33-,34+,35+/m0/s1
74405-42-8Relevant articles and documents
Solid Phase Synthesis of Oligodeoxyribonucleotides Utilizing the Phenylthio Group as a Phosphate Protecting Group
Matsuzaki, Jun-ichi,Kohno, Kyoko,Tahara, Shin-ichiro,Sekine, Mitsuo,Hata, Tsujiaki
, p. 1407 - 1414 (2007/10/02)
Oligodeoxyribonucleotide synthesis utilizing the phenylthio group as a phosphate protecting group was applied to the solid phase method.The base residues of deoxyguanosine and deoxyadenosine were protected with bis(isobutyryloxy)ethylene (Bibe) and phthaloyl groups to avoid the base modfication and depurination, respectively.A key synthetic intermediate of N2-isobutyryl-N1,N2-bis(isobutyryloxy)ethylenedeoxyguanosine was prepared in high yield by four-step reaction from deoxyguanosine and used for preparation of the building blocks of deoxyguanosine required for the polymer support synthesis.Two kinds of polymer supports, i.e., 1 percent cross-linked polystyrene and controlled pore glass were chosen.The latter was employed for the synthesis of dodecadeoxyribonucleotides by using an automated DNA synthesizer.
