74410-97-2 Usage
Description
4-Isothiazolecarboxylic acid, 3-Methyl-, Methyl ester, also known as Methyl 3-Methylisothiazole-4-carboxylate, is an organic compound with the chemical formula C6H7NO2S. It is a derivative of isothiazole carboxylic acid, featuring a methyl group at the 3-position and a methyl ester group at the 4-position. 4-Isothiazolecarboxylic acid, 3-Methyl-, Methyl ester is known for its potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
4-Isothiazolecarboxylic acid, 3-Methyl-, Methyl ester is used as a chemical intermediate for the synthesis of substituted fused pyrimidinamines. These pyrimidinamines act as PI3 kinase modulators, which are important in the development of cancer treatment therapies.
In the context of cancer treatment, 4-Isothiazolecarboxylic acid, 3-Methyl-, Methyl ester plays a crucial role in the preparation of compounds that can modulate the activity of PI3 kinase. This enzyme is a key component in cellular signaling pathways, and its dysregulation has been implicated in various types of cancer. By targeting PI3 kinase, these pyrimidinamines can potentially inhibit tumor growth and proliferation, making them valuable in the development of novel cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 74410-97-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,4,1 and 0 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 74410-97:
(7*7)+(6*4)+(5*4)+(4*1)+(3*0)+(2*9)+(1*7)=122
122 % 10 = 2
So 74410-97-2 is a valid CAS Registry Number.
74410-97-2Relevant articles and documents
HETEROCYCLIC COMPOUNDS AND USES THEREOF
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Paragraph 00562, (2013/03/26)
Compounds and pharmaceutical compositions of formulae (I), (XI) and (XII) as PI3 kinase modulators and their use in the treatment of diseases such as cancer.
HETEROCYCLIC COMPOUNDS AND USES THEREOF
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Paragraph 0770; 0839, (2013/10/22)
Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
Some 1,3-Dipolar Cycloaddition Reactions of Nitrile N-Sulfides with Acetylenes and Olefins
Sanders, Michael J.,Grunwell, John R.
, p. 3753 - 3756 (2007/10/02)
The generation of nitrile N-sulfides from iminosulfur difluorides is general.Trifluoroacetonitrile N-sulfide was allowed to react with some acetylenes and olefins.For example, N-phenylmaleimide gave N-phenyl-3-trifluoromethyl-1,2-thiazoline-4,5-carboximid
