74420-03-4

Basic information

• Product Name: 4-chloro-1H-Pyrrolo[2,3-b]pyridine-7-oxide
• Synonyms: 4-chloro-1H-Pyrrolo[2,3-b]pyridine-7-oxide;1H-Pyrrolo[2,3-b]pyridine, 4-chloro-, 7-oxide
• CAS NO: 74420-03-4
• Molecular Formula: C₇H₅ClN₂O
• Molecular Weight: 168.5804
• Mol File: 74420-03-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-chloro-1H-Pyrrolo[2,3-b]pyridine-7-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-1H-Pyrrolo[2,3-b]pyridine-7-oxide(74420-03-4)
• EPA Substance Registry System: 4-chloro-1H-Pyrrolo[2,3-b]pyridine-7-oxide(74420-03-4)

Safety Data

• Hazardous Substances Data: 74420-03-4(Hazardous Substances Data)

Usage

General Description

4-chloro-1H-Pyrrolo[2,3-b]pyridine-7-oxide is a chemical compound with the molecular formula C7H5ClN2O. It is a pyrrolopyridine derivative with a chlorine atom attached to the fourth position of the pyrrole ring and an oxide group at the seventh position. 4-chloro-1H-Pyrrolo[2,3-b]pyridine-7-oxide is used in pharmaceutical research and development as a building block for the synthesis of various biologically active molecules, including potential drug candidates. It has the potential to exhibit biological activity due to its structural features and can be used as a precursor for the development of new therapeutic agents. However, its specific pharmacological properties and potential applications in medicine have yet to be fully explored.

Upstream product

• 55052-28-3 4-chloro-7-azaindole 

Downstream Products

• 688781-75-1 3-fluoro-4-((1H-pyrrolo [2,3-b]pyridin-4-yl)oxy)aniline 
• 688781-89-7 {4-[(6-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3-fluorophenyl}amine 
• 881902-82-5 3-fluoro-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-phenylamine 
• 881902-81-4 4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-3-fluoro-phenylamine 
• 1171896-08-4 (6-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone 
• 1000340-64-6 6-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine 
• 171879-99-5 4-chloro-6-methyl-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Regioselective deoxygenative chalcogenation of 7-Azindole: N-oxides promoted by I2/PEG-200

We developed a general and sustainable approach for the regioselective deoxygenative chalcogenation of 7-Azindole N-oxides; the combination of an internal oxidant and a green solvent has been used successfully for the synthesis of mono-and dichalcogenyl 7-Azaindoles which are of pharmaceutical interest. The regioselectivity is tunable by the variation of the reaction conditions. I2/PEG was established as an efficient and reusable catalytic system for C-H chalcogenation. This developed methodology has great potential for practical utility, with a broad substrate scope, green reaction conditions, and operational simplicity.

Pyrrolopyrimidines and Pyrrolopyridines

Compounds of formula I in free or salt or solvate form, wherein X, T1, T3 and T4 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Concise and Efficient Synthesis of 4-Fluoro-1H-pyrrolo[2,3-b]pyridine

(Equation presented) Two routes describing the preparation of 4-fluoro-1H-pyrrolo[2,3-b]pyridine (4a) from 1H-pyrrolo[2,3-b]pyridine N-oxide (1) are presented. Regioselective fluorination was achieved using either the Balz-Schiemann reaction or lithium-halogen exchange.