74422-90-5Relevant articles and documents
Total Synthesis and Structural Revision of Clavilactone D
Takao, Ken-Ichi,Nemoto, Ryuichi,Mori, Kento,Namba, Ayumi,Yoshida, Keisuke,Ogura, Akihiro
, p. 3828 - 3831 (2017/03/27)
A structural revision of clavilactone D, a potent inhibitor of protein tyrosine kinases, was achieved by total syntheses of two newly proposed structures. The syntheses relied on ring-opening/ring-closing metathesis, which transformed a cyclobutenecarboxylate into a γ-butenolide. The syntheses confirmed that the correct structure of clavilactone D has an amino group at C-3 instead of a hydroxy group at C-2 in the originally proposed structure.
A practical synthesis of the ansa chain of benzenic ansamycin antibiotics: Total synthesis of an ansatrienol derivative
Kashin, Dmitry,Meyer, Axel,Wittenberg, Ruediger,Schoening, Kai-Uwe,Kamlage, Stefan,Kirschning, Andreas
, p. 304 - 319 (2007/10/03)
A practical and stereocontrolled synthetic approach towards the ansa chain of the benzenic ansamycins (mycotrienins) is described, which can be scaled up to multigram quantities. Key features of the synthesis are the formation of the Z-configured tri-subs
Asymmetric synthesis of the benzoquinoid ansamycin antitumor antibiotics: Total synthesis of (+)-macbecin
Evans,Miller,Ennis
, p. 471 - 485 (2007/10/02)
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