74436-00-3

Basic information

• Product Name: Geclosporin
• Synonyms: Geclosporin;cyclosporin G;(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Nva-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);Cyclo(((2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl);Cyclosporin A, 7-L-norvaline-;Ring spore fungus element
• CAS NO: 74436-00-3
• Molecular Formula: C63H113N11O12
• Molecular Weight: 1216.65
• Mol File: 74436-00-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 196-197°
• Boiling Point: 1297.8°C at 760 mmHg
• Flash Point: 738.7°C
• Appearance: /
• Density: 1.013g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.467
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.32±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Geclosporin(CAS DataBase Reference)
• NIST Chemistry Reference: Geclosporin(74436-00-3)
• EPA Substance Registry System: Geclosporin(74436-00-3)

Safety Data

• Hazardous Substances Data: 74436-00-3(Hazardous Substances Data)

Usage

Description

Geclosporin G is a derivative of Cyclosporin A, which is a nonpolar cyclic oligopeptide known for its immunosuppressive properties. It has played a significant role in the field of organ transplantation by effectively preventing graft rejection.

Uses

Used in Organ Transplantation:
Geclosporin G is used as an immunosuppressant in the organ transplantation industry to prevent graft rejection. Its immunosuppressive activity helps in reducing the risk of the recipient's immune system attacking the transplanted organ, thus increasing the chances of a successful transplant.
Used in Pharmaceutical Industry:
Geclosporin G is also used in the pharmaceutical industry as a key component in the development of drugs that target the immune system. Its immunosuppressive properties make it a valuable asset in the treatment of various autoimmune diseases and conditions where the immune system is overactive or needs to be regulated.

InChI:InChI=1/C63H113N11O12/c1-25-27-29-41(15)53(76)52-57(80)66-44(28-26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27,35-48,50-53,76H,26,28-34H2,1-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b27-25+