74464-84-9Relevant articles and documents
PROCESS FOR PRODUCING LOW-MELTING CRYSTAL OF FREE DISOPYRAMIDE BASE
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Page/Page column 5, (2008/06/13)
The present invention provides a production method of a low melting point type crystal of disopyramide free base, which comprises a step of dissolving disopyramide free base in a solvent, a step of crystallizing the disopyramide free base from the obtained solution and a step of aging the crystal of the disopyramide free base, wherein the solvent is a mixed solvent of toluene and one or two kinds of hydrocarbon solvents selected from heptane and hexane. According to the present invention, a method capable of stably producing a low melting point type crystal of disopyramide free base on an industrial scale in a high yield can be provided.
(-)-α-{2-[Bis(1-methylethyl)amino]ethyl}-α-phenyl-2-pyridineacetamide and pharmacologically acceptable salts thereof
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, (2008/06/13)
Preparation of antiarrhythmic (-)-α-{2-[bis(1-methylethyl)amino]ethyl}-α-phenyl-2-pyridineacetamide and pharmacologically acceptable salts thereof characterized by advantageously diminished and/or favorably altered side-effects such as anticholinergic activity is disclosed.