7448-86-4

Basic information

• Product Name: 1-(4-methoxyphenyl)prop-2-en-1-one
• Synonyms: 1-(4-Methoxyphenyl)-2-propen-1-one; 2-propen-1-one, 1-(4-methoxyphenyl)-
• CAS NO: 7448-86-4
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.1852
• Mol File: 7448-86-4.mol
• Article Data: 74

Chemical Properties

• Boiling Point: 266.2°C at 760 mmHg
• Flash Point: 116.2°C
• Density: 1.035g/cm³
• Vapor Pressure: 0.00875mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: 1-(4-methoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)prop-2-en-1-one(7448-86-4)
• EPA Substance Registry System: 1-(4-methoxyphenyl)prop-2-en-1-one(7448-86-4)

Safety Data

• Hazardous Substances Data: 7448-86-4(Hazardous Substances Data)

Usage

Safety Profile

A questionable carcinogen. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating vapors.

Upstream product

• 2125-49-7 3-dimethylamino-1-(4-methoxy-phenyl)-propan-1-one; hydrochloride 
• 100-66-3 methoxybenzene 
• 625-36-5 2-chloropropionyl chloride 
• 51410-44-7 1-(4-methoxylphenyl)-2-propen-1-ol 
• 33994-11-5 α-Bromoethyl p-methoxaphenyl ketone 
• 95605-45-1 [3-(4-methoxy-phenyl)-3-oxo-propyl]-trimethyl-ammonium; bromide 
• 18096-70-3 3-dimethylamino-4'-methoxyacrylophenone 
• 87015-46-1 1-(4-methoxyphenyl)-3-tosylpropan-1-one 
• 87015-44-9 3-((4-chlorophenyl)sulfonyl)-1-(4-methoxyphenyl)propan-1-one 
• 77253-67-9 trifluoroethanol-d₃ 
• 81112-07-4 2-chloro-1-(4'-methoxyphenyl)-propan-1-one 
• 3153-44-4 4-(4-methoxy-phenyl)-4-oxo-butyric acid 
• 201230-82-2 carbon monoxide 
• 7486-35-3 tri-n-butyl(vinyl)tin 

Downstream Products

• 103990-59-6 N,N-bis-[3-(4-methoxy-phenyl)-3-oxo-propyl]-O-methyl-hydroxylamine 
• 121-97-1 4-Methoxypropiophenone 
• 3314-43-0 3-(4-methoxy-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazole 
• 67756-15-4 1-(4-Methoxyphenyl)-1,4-decandion 
• 60755-22-8 1-(4-methoxyphenyl)-4-phenyl-1,4-butanedione 
• 15982-64-6 1,4-bis(4-methoxyphenyl)butane-1,4-dione 
• 2108-54-5 1-(4-methoxyphenyl)pentane-1,4-dione 
• 54605-99-1 (4-methoxyphenyl)(3-methyl-4,5-dihydroioxazol-5-yl)methanone 
• 87015-46-1 1-(4-methoxyphenyl)-3-tosylpropan-1-one 
• 143619-29-8 (S)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester 
• 143619-29-8 (R)-2-Cyano-5-(4-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester 
• 87015-44-9 3-((4-chlorophenyl)sulfonyl)-1-(4-methoxyphenyl)propan-1-one 
• 130767-31-6 (E)-3-(2,4-Dimethoxy-pyrimidin-5-yl)-1-(4-methoxy-phenyl)-propenone 
• 14006-70-3 3-indol-3-yl-1-(4-methoxy-phenyl)-propan-1-one 

Relevant articles and documents

Rational modification of Mannich base-type derivatives as novel antichagasic compounds: Synthesis, in vitro and in vivo evaluation

The current chemotherapy against Chagas disease is inadequate and insufficient. A series of ten Mannich base-type derivatives have been synthesized to evaluate their in vitro antichagasic activity. After a preliminary screening, compounds 7 and 9 were sub

Rongalite as C1 Synthon and Sulfone Source: A Practical Sulfonylmethylation Based on the Separate-Embedding Strategy

Rongalite has been used in several challenging synthetic transformations with operationally simple and effective protocols. However, the employment of multiple characteristics of rongalite in synthetic chemistry is comparatively little known. Herein we report a separate-embedding type sulfonylmethylation of sulfoxonium ylides in which rongalite concurrently acted as a sulfone source, C1 synthon, radical initiator, and potential reducing reagent for the first time. Notably, this facile and easy-handling reaction does not require a catalyst or prefunctionalized sulfonylmethylation reagents.

Generation of α-Boryl Radicals and Their Conjugate Addition to Enones: Transition-Metal-Free Alkylation of gem-Diborylalkanes

A transition-metal-free method for the alkylation of gem-diborylalkanes with α,β-unsaturated ketones has been developed. It is demonstrated that the α-boryl radicals can be generated efficiently from gem-diborylalkanes with the aid of catechol and oxidants. The α-boryl radicals formed through such process can be engaged in conjugate addition reaction with α,β-unsaturated ketones. This transformation is a straightforward method for the synthesis of γ-borylketones.

Metabolically stable vanillin derivatives for the treatment of hypoxia

Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.