744993-61-1

Basic information

• Product Name: N-(3-cyanobenzyl)aniline
• Synonyms: N-(3-cyanobenzyl)aniline
• CAS NO: 744993-61-1
• Molecular Weight: 208.263
• Mol File: 744993-61-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-(3-cyanobenzyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-cyanobenzyl)aniline(744993-61-1)
• EPA Substance Registry System: N-(3-cyanobenzyl)aniline(744993-61-1)

Safety Data

• Hazardous Substances Data: 744993-61-1(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 64407-07-4 3-(chloromethyl)benzonitrile 
• 7647-01-0 hydrogenchloride 
• 24964-64-5 3-Cyanobenzaldehyde 
• 874-97-5 3-(hydroxymethyl)benzonitrile 
• 28188-41-2 m-(bromomethyl)benzonitrile 

Relevant articles and documents

Mechanistic Insight into Hydroboration of Imines from Combined Computational and Experimental Studies

Boron Lewis acid-catalyzed and catalyst-free hydroboration reactions of imines are attractive due to the mild reaction conditions. In this work, the mechanistic details of the hydroboration reactions of two different kinds of imines with pinacolborane (HB

Cp*Ir-catalyzed N-alkylation of amines with alcohols. A versatile and atom economical method for the synthesis of amines

A versatile and highly atom economical catalytic system consisting of [Cp*IrCl2]2/NaHCO3 (Cp*=pentamethylcyclopentadienyl) for the N-alkylation of amines with primary and secondary alcohols as alkylating reagents has been developed. For example, the reaction of equimolar amounts of aniline and benzyl alcohol in the presence of [Cp*IrCl2]2 (1.0 mol % Ir) and NaHCO3 (1.0 mol %) in toluene at 110 °C gives N-benzylaniline in 94% yield. The present catalytic system is applicable to the N-alkylation of both primary and secondary amines, and only harmless water is produced as co-product. A wide variety of secondary and tertiary amines can be synthesized with high atom economy under mild and less-toxic conditions. One-pot sequential N-alkylation leading to tertiary amines bearing three different substituents is also described.

EFFECTS OF SUBSTITUENTS IN THE BENZYL BROMIDE ON THE KINETICS OF THE BENZYLATION OF AMINES

The kinetics of the reactions of 3- and 4-substituted benzyl bromides with amines having various structures in nitrobenzene at 40 deg C were investigated.The 4-substituted benzyl bromides have higher reactivity compared with that calculated on the basis of the linear correlations according to the Hammett-Taft equation for unsubstituted and 3-substituted benzyl bromides containing electron-withdrawning substituents.The reactivity of benzyl bromides containing electron-donating substituents obeys a linear correlation with the ?+ constants.The effects of structural changes in the substrate and the nucleophile on the character of the transition states of the investigated reactions is discussed.