7450-69-3Relevant articles and documents
Bicyclo-imidazoline laurate, synthesis method therefor and application of bicyclo-imidazoline laurate
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Paragraph 0057; 0058; 0062; 0069; 0076, (2018/07/06)
The invention discloses bicyclo-imidazoline laurate. The bicyclo-imidazoline laurate has a symmetrical molecular structure, comprises two imidazoline heterocycles and two alkyl long chains of lauric acid, and thus, plenty and dense electronic clouds and good hydrophobicity can be provided. The invention further discloses a bicyclo-imidazoline laurate synthesis method, which is low in raw materialcost and high in reaction yield and can achieve industrial production. The invention further discloses an application of the bicyclo-imidazoline laurate. The electrotransport type cationic bicyclo-imidazoline laurate is obtained through activating bicyclo-imidazoline laurate and is applied to the rusting prevention of reinforced concrete.
Design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors
Dominguez, Maria J.,Sanmartin, Carmen,Font, Maria,Palop, Juan A.,San Francisco, Sara,Urrutia, Oscar,Houdusse, Fabrice,Garcia-Mina, Jose M.
experimental part, p. 3721 - 3731 (2010/03/05)
The design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors to reduce the loss of ammonia has been carried out. Forty phosphorus derivatives were synthesized and their inhibitory activities evaluated against that of jack bean urease. In addition, in vivo assays have been carried out. All of the compounds were characterized by IR, 1H NMR, MS, and elemental microanalysis. In some cases, detailed molecular modeling studies were carried out, and these highlighted the interaction between the enzyme active center and the compounds and also the characteristics related to their activity as urease inhibitors. According to the IC50 values for in vitro inhibitory activity, 12 compounds showed values below 1 μM and 8 of them represent improvements of activity in comparison to the commercial urease inhibitor N-n-butylthiophosphorictriamide (NBPT) (100 nM) (AGROTAIN). On the basis of the activity results and the conclusions of the molecular modeling study, a structural model for new potential inhibitors has been defined.
Synthesis of Phenyl Phosphorodiamidates
Roth, Hermann J.,Lenig, Arthur R.,Stock, Wilfried
, p. 85 - 91 (2007/10/02)
Two procedures are described for the synthesis of phenyl phosphorodiamidates in high yields.These compounds can be represented by the general formula 6 and are used for cyclisation reactions leading to phosphabarbituric acids.