745048-07-1

Basic information

• Product Name: 1-BOC-4-(4-AMINOBUTYL)PIPERAZINE
• Synonyms: BUTTPARK 90\06-07;1-BOC-4-(4-AMINOBUTYL)PIPERAZINE;4-(4-Amino-butyl)-piperazine-1-carboxylicacidtert-butylester;tert-butyl 4-(4-aminobutyl)piperazine-1-carboxylate;1-Piperazinecarboxylicacid, 4-(4-aminobutyl)-, 1,1-dimethylethyl ester
• CAS NO: 745048-07-1
• Molecular Formula: C₁₃H₂₇N₃O₂
• Molecular Weight: 257.37
• Product Categories: pharmacetical
• Mol File: 745048-07-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 353.8°C at 760 mmHg
• Flash Point: 167.7°C
• Appearance: /
• Density: 1.029g/cm³
• Vapor Pressure: 3.51E-05mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: 1-BOC-4-(4-AMINOBUTYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-(4-AMINOBUTYL)PIPERAZINE(745048-07-1)
• EPA Substance Registry System: 1-BOC-4-(4-AMINOBUTYL)PIPERAZINE(745048-07-1)

Safety Data

• Hazardous Substances Data: 745048-07-1(Hazardous Substances Data)

Usage

General Description

1-BOC-4-(4-AMINOBUTYL)PIPERAZINE is a specialized chemical compound commonly used in chemical and pharmaceutical research. Its basic backbone structure comprises a piperazine ring, which is a common feature in many pharmaceutical drugs due to its ability to increase solubility and absorption. It is also characterized by having BOC (tert-butyloxycarbonyl) and an aminobutyl group. The BOC group is specifically used in organic chemistry as a protective group for amines, preserving the structure during synthesis processes. This chemical compound plays a significant role in the synthesis of complex organic molecules, possibly involving peptide or drug synthesis, and is valuable in the field of medicinal chemistry.

InChI:InChI=1/C13H27N3O2/c1-13(2,3)18-12(17)16-10-8-15(9-11-16)7-5-4-6-14/h4-11,14H2,1-3H3

Upstream product

• 745048-06-0 4-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyl]piperazine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 1351412-06-0 tert-butyl 4-(4-(cyclohexylmethylsulfonamido)butyl)piperazine-1-carboxylate 
• 1351412-07-1 1-cyclohexyl-N-(4-(piperazin-1-yl)butyl)methanesulfonamide 
• 1351412-08-2 1-cyclohexyl-N-(4-(4-(6-nitropyridin-2-yl)piperazin-1-yl)butyl)methane-sulfonamide 

Relevant articles and documents

PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)

PYRIDINYL DERIVATIVES COMPRISING A CYANOGUANIDINE OR SQUARIC ACID MOIETY

The present application discloses compounds of the formula (I) wherein X = opt.subst. pyrid-3-yl or pyrid-4-yl; Q = opt.subst. Ci-6 alkylene or a single bond; Y is formula (i) wherein D is = N-CN, or formula (ii) B = is opt.subst. C1-6 alkylene; A = (formula) Z = -J-V, wherein J = -C(=0)-, -C(=O)-O, -S(=O)2-, -P(=O)(OR4)-, -C(=O)-NR4- and -C(=S)-NR4-, and V = opt.subst. C1-12-alkyl, opt.subst. C3-12-cycloalkyl, -[CH2CH2O]1-10-( opt.subst. C1-6-alkyl), opt.subst. C1-12- alkenyl, opt.subst. aryl, opt.subst. heterocyclyl, or opt.subst. heteroaryl; q = 0-2, and r = 0- 2; and pharmaceutically acceptable salts thereof, and prodrugs thereof. The application also discloses the compound for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT), e.g. inflammatory and tissue repair disorders; dermatosis; autoimmune diseases, Alzheimer's disease, stroke, athersclerosis, restenosis, diabetes, glomerulonephritis, cancer, cachexia, inflammation associated with infection and certain viral infections, including Acquired Immune Deficiency Syndrome (AIDS), adult respiratory distress syndrome, ataxia telengiectasia.