74510-32-0

Basic information

• Product Name: 2,6,6-Trimethyl-6-<(4-methylphenylsulfonyloxy)methyl>cyclohexanon
• Synonyms: 2,6,6-Trimethyl-6-<(4-methylphenylsulfonyloxy)methyl>cyclohexanon
• CAS NO: 74510-32-0
• Molecular Weight: 324.441
• Mol File: 74510-32-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6,6-Trimethyl-6-<(4-methylphenylsulfonyloxy)methyl>cyclohexanon(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6,6-Trimethyl-6-<(4-methylphenylsulfonyloxy)methyl>cyclohexanon(74510-32-0)
• EPA Substance Registry System: 2,6,6-Trimethyl-6-<(4-methylphenylsulfonyloxy)methyl>cyclohexanon(74510-32-0)

Safety Data

• Hazardous Substances Data: 74510-32-0(Hazardous Substances Data)

Upstream product

• 74523-53-8 2-(Hydroxymethyl)-2,6,6-trimethylcyclohexanol 
• 7507-68-8 1,3,3-trimethyl-2-oxocyclohexanecarboxylic acid ethyl ester 
• 74510-31-9 2,6,6-Trimethyl-6-<(4-methylphenylsulfonyloxy)methyl>cyclohexanol 

Downstream Products

• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 74510-34-2 2,6,6-Trimethyl-6-heptensaeure-methylester 
• 74510-33-1 2-(Methoxymethyl)-2,6,6-trimethylcyclohexanon 

Relevant articles and documents

Fragmentierungsreaktionen an Carbonylverbindungen mit β-staendigen elektronegativen Substituenten, XXXIII 3-Oxatricyclo1,4>undec-4-en, ein stark gespannter Vierring-Enolether

The behaviour of β-keto tosylates against nucleophiles has been investigated.The keto tosylate 6 underwent intramolecular cyclization with KOtBu in ether to produce exclusively the four-membered O-alkylated product 18 (the title compound).The substitution products 5 or 7 are obtained from 6 with NaOMe in methanol or KCN in DMSO, resp.Reaction of 6 with MeLi yielded the diol 13.The keto tosylate 31 reacted with MeLi analogously to form the diol 28, whereas with MeMgI a mixture of the Grob fragmentation product 33 and the alcohol 32 (via 28 by H2O elimination) was produced.Similarly keto tosylate 22b and MeMgI yielded the alcohol 27. - The non-enolizable keto tosylate 44 undergoes very slow reaction wih NaOH/MeOH to produce 41, 42, and 45 in low yield.