74539-08-5Relevant articles and documents
Synthesis of Potential Inhibitors of Hypoxanthine-Guanine Phosphoribosyltransferase for Testing as Antiprotozoal Agents. 2. 1-Substituted Hypoxanthines
Piper, James R.,Laseter, Anne G.,Johnston, Thomas P.,Montgomery, John A.
, p. 1136 - 1139 (2007/10/02)
Evidence indicating that effective in vivo inibition of hypoxanthine-guanine phosphoribosyltransferase (HGPRT, EC 2.4.2.8) should produce antiprotozoal activity without significant toxic effects on mammalian hosts prompted syntheses of 1-substituted hypox