74542-54-4

Basic information

• Product Name: N,N-phenyl-p-toluenesulfonylbenzamide
• Synonyms: N,N-phenyl-p-toluenesulfonylbenzamide
• CAS NO: 74542-54-4
• Molecular Weight: 351.426
• Mol File: 74542-54-4.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: N,N-phenyl-p-toluenesulfonylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-phenyl-p-toluenesulfonylbenzamide(74542-54-4)
• EPA Substance Registry System: N,N-phenyl-p-toluenesulfonylbenzamide(74542-54-4)

Safety Data

• Hazardous Substances Data: 74542-54-4(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 62-53-3 aniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 65-85-0 benzoic acid 
• 93-98-1 N-phenyl benzoyl amide 
• 68-34-8 phenyl toluenesulfonamide 

Downstream Products

• 93-98-1 N-phenyl benzoyl amide 
• 74542-57-7 N-benzoylamino-4-benzoylaminodiphenylamine 
• 74542-56-6 N-[4-(Toluene-4-sulfonyl)-phenyl]-benzamide 
• 74542-55-5 N-[2-(Toluene-4-sulfonyl)-phenyl]-benzamide 
• 1527-91-9 N-phenylbenzamidine 
• 2556-46-9 N,N'-diphenylbenzamidine 
• 68-34-8 phenyl toluenesulfonamide 
• 65-85-0 benzoic acid 
• 134-84-9 4-Methylbenzophenone 
• 611-94-9 4-Methoxybenzophenone 
• 345-83-5 4-fluorobenzophenone 
• 6158-54-9 methyl 4-Benzoylbenzoate 
• 1503-49-7 p-cyanobenzophenone 
• 53689-84-2 4-acetylbenzophenone 

Relevant articles and documents

Pd-Catalyzed Double-Decarbonylative Aryl Sulfide Synthesis through Aryl Exchange between Amides and Thioesters

We report the palladium-catalyzed double-decarbonylative synthesis of aryl thioethers by an aryl exchange reaction between amides and thioesters. In this method, amides serve as aryl donors and thioesters are sulfide donors, enabling the synthesis of valuable aryl sulfides. The use of Pd/Xantphos without any additives has been identified as the catalytic system promoting the aryl exchange by C(O)-N/C(O)-S cleavages. The method is amenable to a wide variety of amides and sulfides.

N-Aroylsulfonamide-Photofragmentation (ASAP)-A Versatile Route to Biaryls

The photochemical fragmentation of N-aroylsulfonamides 9 (ASAP) is a powerful method for the preparation of various biaryls. Compounds 9 are easily accessible in two steps from amines by treatment with arenesulfonyl chlorides and aroyl chlorides. Many of these compounds were prepared for the first time. The irradiation takes place in a previously developed continuous-flow reactor using inexpensive UVB or UVC fluorescent lamps. Isocyanates and sulphur dioxide are formed as the only by-products. The ASAP tolerates a variety of functional groups and is even suited for the preparation of phenylnaphthalenes and terphenyls. The ASAP mechanism was elucidated by interaction of photophysical and quantum chemical (DFT) methods and revealed a spirocyclic biradical as key intermediate.

Transamidation for the Synthesis of Primary Amides at Room Temperature

Various primary amides have been synthesized using the transamidation of various tertiary amides under metal-free and mild reaction conditions. When (NH4)2CO3 reacts with a tertiary amide bearing an N-electron-withdrawing substituent, such as sulfonyl and diacyl, in DMSO at 25 °C, the desired primary amide product is formed in good yield with good funcctional group tolerance. In addition, N-tosylated lactam derivatives afforded their corresponding N-tosylamido alkyl amide products via a ring opening reaction.