74568-14-2

Basic information

• Product Name: (7RS)-<7-(2)H1>-7,8-dihydrofolic acid
• CAS NO: 74568-14-2
• Molecular Weight: 444.411
• Mol File: 74568-14-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (7RS)-<7-(2)H1>-7,8-dihydrofolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (7RS)-<7-(2)H1>-7,8-dihydrofolic acid(74568-14-2)
• EPA Substance Registry System: (7RS)-<7-(2)H1>-7,8-dihydrofolic acid(74568-14-2)

Safety Data

• Hazardous Substances Data: 74568-14-2(Hazardous Substances Data)

Upstream product

• 59-30-3 folic acid 
• 4033-27-6 (S)-2-{4-[(2-Amino-4-oxo-3,4,7,8-tetrahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid 

Downstream Products

• 98814-61-0 (6RS,7RS)-<7-(2)H>-5-formyl-5,6,7,8-tetrahydrofolic acid 

Relevant articles and documents

Stereochemistry of Reduction of the Vitamin Folic acid by Dihydrofolate Reductase

Reduction of the vitamin folic acid (6) to the coenzyme 5,6,7,8-tetrahydrofolic acid (1) by the enzyme dihydrofolate reductase is shown to involve transfer of the 4-pro R hydrogen of NADPH to the same face at both C-6 and C-7 of the pteridine system (the re face at C-6 and the si face at C-7).The orientations of the pteridine system of folic acid (6) and of dihydrofolic acid (5) when bound to the enzyme are different from the orientation of the pteridine ring of the anti-cancer drug methotrexate (11) when bound to this enzyme.