74572-10-4

Basic information

• Product Name: 2-methyl-4-(toluene-4-sulfonyl)-morpholine
• Synonyms: 2-methyl-4-(toluene-4-sulfonyl)-morpholine
• CAS NO: 74572-10-4
• Molecular Weight: 255.338
• Mol File: 74572-10-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-methyl-4-(toluene-4-sulfonyl)-morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-(toluene-4-sulfonyl)-morpholine(74572-10-4)
• EPA Substance Registry System: 2-methyl-4-(toluene-4-sulfonyl)-morpholine(74572-10-4)

Safety Data

• Hazardous Substances Data: 74572-10-4(Hazardous Substances Data)

Upstream product

• 929278-92-2 {(2R)-4-[(4-methylphenyl)sulfonyl]-2-morpholinyl}methanol 
• 1268368-72-4 (S,E)-2-(3-methylbut-1-enyl)-4-tosylmorpholine 
• 1268368-60-0 (R,Z)-N-(4-hydroxy-5-methylhex-2-enyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide 
• 1268368-83-7 (R)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-N-(4-hydroxy-5-methylhex-2-ynyl)-4-methylbenzenesulfonamide 
• 1015445-11-0 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide 
• 1257237-54-9 N-[(2S)-2-hydroxypropyl]-4-methylbenzenesulfonamide 
• 247129-85-7 (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate 
• 98-59-9 p-toluenesulfonyl chloride 
• 74572-07-9 (S)-1-((2-hydroxyethyl)amino)propan-2-ol 
• 454251-71-9 (2S,4aS,7R,8aR)-N-allyl-2-hydroxymethyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine 
• 914359-78-7 (3R,6aS,9R,10aR,11aS)-3-phenylselenenylmethyl-6,6,9-trimethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine 
• 914360-07-9 (2S)-4-(8-mentholyl)-2-methyl-morpholine 
• 914359-94-7 (3S,6aS,9R,10aR,11aS)-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine 
• 74572-13-7 (2S)-2-methyl-morpholine 

Downstream Products

• 74572-13-7 (2S)-2-methyl-morpholine 

Relevant articles and documents

Stereoselective synthesis of c-substituted morpholine derivatives using reductive etherification reaction: Total synthesis of chelonin C

A general strategy is developed for the stereoselective synthesis of C-substituted morpholine derivatives using intramolecular reductive etherification reaction. The method is extended to the first stereoselective total synthesis of (±)-chelonin C.

DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS

Compound formula I: wherein: X1 and X2 may be either (a) C and O, (b) N and N, or (c) C and NH, where the dotted bonds represents a double bond in the appropriate location; R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, or an optionally substituted C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; RN1 is selected from hydrogen and an optionally substituted C1-4 alkyl group; RC1 is selected from an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, or an optionally substituted C5-20 aryl group; or RN1 and RC1 may together form an optionally substituted C2-4 alkylene group.

SYNTHESIS AND ABSOLUTE CONFIGURATION OF SUBSTITUTED MORPHOLINES

We studied methods of stereospecific synthesis that enabled us to obtain variously substituted morpholinic compounds and to determine their absolute configuration.From a study of the chiroptical properties of synthetic N-(2-pyridyl-N-oxide) derivatives of optically active morpholines, it was possible to correlate the sign of the Cotton effect with the absolute configuration.This correlation agrees with that previously established for derivatives of the piperidine type.By evaluating the various contributions to the Cotton effect of substituents in positions 2 and 3, we established the absolute configuration of bicyclic compounds condensed in the two positions mentioned above.