7462-94-4

Basic information

• Product Name: 2-hydroxy-2-Methyl-1-(2-pyridinyl)-1-Propanone
• Synonyms: 2-hydroxy-2-Methyl-1-(2-pyridinyl)-1-Propanone;NSC 402143
• CAS NO: 7462-94-4
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.18914
• Mol File: 7462-94-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 271 °C at 760 mmHg
• Flash Point: 117.7 °C
• Appearance: /
• Density: 1.141 g/cm³
• Vapor Pressure: 0.00325mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: 2-hydroxy-2-Methyl-1-(2-pyridinyl)-1-Propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-2-Methyl-1-(2-pyridinyl)-1-Propanone(7462-94-4)
• EPA Substance Registry System: 2-hydroxy-2-Methyl-1-(2-pyridinyl)-1-Propanone(7462-94-4)

Safety Data

• Hazardous Substances Data: 7462-94-4(Hazardous Substances Data)

Usage

General Description

1-(2-pyridinyl)-1-propanone is a chemical compound with the formula C8H9NO2. It is a colorless to pale yellow liquid with a strong odor. 2-hydroxy-2-Methyl-1-(2-pyridinyl)-1-Propanone is commonly used as a flavoring agent and in the production of fragrances. It is also used as a solvent and in the manufacture of pharmaceuticals. This chemical is considered hazardous and may cause irritation to the skin, eyes, and respiratory system. It may also be harmful if swallowed or inhaled and should be handled with care.

InChI:InChI=1/C9H11NO2/c1-9(2,12)8(11)7-5-3-4-6-10-7/h3-6,12H,1-2H3

Upstream product

• 59576-30-6 2-methyl-1-(pyridin-2-yl)propan-1-one 

Relevant articles and documents

Α - hydroxy ketone compound low priced high-efficient synthetic method

The invention discloses a cheap and efficient synthesis method of an alpha-hydroxyketone compound. The synthesis method is characterized in that a carbonyl compound undergoes an oxidation hydroxylation reaction at 10-120DEG C under normal pressure with iodine simple substance, N-bromosuccimide, copper bromide, bromine simple substance, hydrogen bromide, N-iodosuccimide or hydrogen iodide as a catalyst, sulfoxide as an oxidant, water or sulfoxide as a hydroxy source and sulfoxide, ethyl acetate, N,N-dimethyl formamide, acetonitrile, toluene, 1,4-dioxane, 1,2-dichloroethane, tetrahydrofuran or H2O as a solvent, and converts into the alpha-hydroxyketone compound in a high selectivity manner. Compared with traditional synthesis methods, the method disclosed in the invention has the advantages of simple operation, high yield, simple conditions, easy purification, small waste discharge amount, simple reaction apparatus, and easy industrial production. The method has wide applicability and can be used for synthesizing various alpha-hydroxyketone compounds.

α-Hydroxyacylation of Pyridine

Efficient synthesis of 2-α-hydroxyacylpyridines 10 starting from pyridine N-oxide and 2-bromoaldehydes via base-induced rearrangement of the resulting N-alkoxypyridinium salts 6 is described.