7463-56-1

Basic information

• Product Name: TETRAZOLO[1,5-A]PYRIDINE-8-CARBOXYLIC ACID
• Synonyms: TETRAZOLO[1,5-A]PYRIDINE-8-CARBOXYLIC ACID;[1,2,3,4]tetrazolo[1,5-a]pyridine-8-carboxylic acid;3-isoquinolinecarboxylic acid, 1,2-dihydro-1-oxo-;8-tetrazolo[1,5-a]pyridinecarboxylic acid
• CAS NO: 7463-56-1
• Molecular Formula: C₆H₄N₄O₂
• Molecular Weight: 164.12
• Mol File: 7463-56-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.79g/cm³
• Refractive Index: 1.821
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: TETRAZOLO[1,5-A]PYRIDINE-8-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAZOLO[1,5-A]PYRIDINE-8-CARBOXYLIC ACID(7463-56-1)
• EPA Substance Registry System: TETRAZOLO[1,5-A]PYRIDINE-8-CARBOXYLIC ACID(7463-56-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 7463-56-1(Hazardous Substances Data)

Usage

General Description

Tetrazolo[1,5-a]pyridine-8-carboxylic acid, also known as TTPC, is a heterocyclic compound with a tetrazole ring and a pyridine ring. It is used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and ability to serve as a bioisostere for carboxylic acids. TTPC has been studied for its potential biological and pharmacological activities, including as an anti-inflammatory and anti-cancer agent. Its chemical structure makes it a valuable tool for drug discovery and development, and its versatility has led to its use in various fields of research and industry.

InChI:InChI=1/C6H4N4O2/c11-6(12)4-2-1-3-10-5(4)7-8-9-10/h1-3H,(H,11,12)

Upstream product

• 2942-59-8 2-chloronicotinic acid 

Downstream Products

• 41803-82-1 3-Methyl-2-phenylpyrido<2,3-d>pyrimidin-4(3H)-on 

Relevant articles and documents

Dual Reactivity of 1,2,3,4-Tetrazole: Manganese-Catalyzed Click Reaction and Denitrogenative Annulation

A general catalytic method using a Mn-porphyrin-based catalytic system is reported that enables two different reactions (click reaction and denitrogenative annulation) and affords two different classes of nitrogen heterocycles, 1,5-disubstituted 1,2,3-triazoles (with a pyridyl motif) and 1,2,4-triazolo-pyridines. Mechanistic investigations suggest that although the click reaction likely proceeds through an ionic mechanism, which is different from the traditional click reaction, the denitrogenative annulation reaction likely proceeds via an electrophilic metallonitrene intermediate rather than a metalloradical intermediate. Collectively, this method is highly efficient and offers several advantages over other methods. For example, this method excludes a multi-step synthesis of the N-heterocyclic molecules described and produces only environmentally benign N2 gas a by-product.

Pyridine-phosphinimine ligand-accelerated Cu(I)-catalyzed azide-alkyne cycloaddition for preparation of 1-(pyridin-2-yl)-1,2,3-triazole derivatives

A series of phosphinimine ligands were designed and used in the Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of tetrazolo[1,5-a]pyridines and alkynes for the first time. By optimizing the reaction conditions, an efficient catalytic system (CuCl/2-PyCH 2NPtBu3) was developed to give 1-(pyridin-2-yl)-1,2,3-triazole derivatives in moderate to excellent yields (46-98%). This journal is the Partner Organisations 2014.